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Carob leaves: Phytochemistry, antioxidant properties, vasorelaxant effect and mechanism of action.
J Ethnopharmacol
December 2024
Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Oujda, 60000, Morocco. Electronic address:
Ethnopharmacological Relevance: Ceratonia siliqua L., is a species of significant nutritional and industrial interest with extensive traditional uses. This fabaceae is renowned for its medicinal properties, including the treatment of high blood pressure.
View Article and Find Full Text PDFEffect of a pre-calving injectable trace mineral supplement on white blood cell function in seasonally calving pastoral dairy cows.
N Z Vet J
October 2024
Tāwharau Ora - School of Veterinary Science, Massey University, Palmerston North, New Zealand.
Aims: To investigate the effect of injection of trace mineral supplement (TMS) 14-28 days before calving on white blood cell count (WBCC) and function, serum antioxidant capacity (SAC) and reactive oxygen species (ROS) in pasture-fed cattle after calving.
Methods: On each of two South Island, seasonally calving, pastoral dairy farms,1 month before dry-off, a random sample of 150 multiparous cows predicted to calve within 7 days of the herd's planned start of calving (PSC) were stratified on individual somatic cell count, age, breed and expected calving date. On each farm, 14-24 days before PSC, 60 selected cows were randomly assigned for TMS (Zn, Mn, Se, Cu) injection, and 60 were controls.
Late-onset renal TMA and tubular injury in cobalamin C disease: a report of three cases and literature review.
BMC Nephrol
October 2024
Renal Division, Department of Medicine, Peking University First Hospital, No. 8 Xishiku St., Xicheng District, Beijing, 100034, China.
Article Synopsis
- Mutation of the MMACHC gene causes cobalamin C disease (cblC), leading to symptoms like metabolic disorders and kidney issues, including thrombotic microangiopathy (TMA).
- Three teenage patients were diagnosed with renal complications from cblC, showing symptoms such as hematuria and hypertension, with tests confirming elevated homocysteine and kidney damage.
- Early diagnosis and treatment with hydroxocobalamin, betaine, and L-carnitine significantly improved their condition, underscoring the need for awareness of cblC in patients with unexplained kidney injury.
Article Synopsis
- Vitamin B12 deficiency can lead to serious neurological issues, including developmental and epileptic encephalopathy, which is rare in infants.
- A case study presented an 11-month-old girl experiencing severe seizures and developmental delays caused by a mutation in the FUT2 gene that affects vitamin B12 absorption.
- Following diagnosis, she was treated with intramuscular hydroxocobalamin, highlighting the importance of identifying genetic causes of vitamin deficiencies in similar cases.
Acute cyanide intoxication due to apricot seed ingestion.
Arch Argent Pediatr
February 2025
Department of Pediatrics, Mardin Artuklu University, Mardin, Turkey.
Article Synopsis
- Cyanide poisoning poses a serious risk to both adults and children, particularly in agricultural areas where consumption of cyanide-containing seeds, like apricot kernels and almonds, can occur.
- A study analyzed 14 children aged 1-18 who were treated for cyanide poisoning in a Pediatric Intensive Care Unit between 2017 and 2022, finding that symptoms often included weakness and fatigue, with most cases happening in July.
- Treatment with hydroxocobalamin was administered to some patients, and it was concluded that cyanide poisoning should be suspected in pediatric cases with sudden unconsciousness and metabolic acidosis, especially if there is a history of consuming certain seeds.
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