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Article Synopsis
- Vitamin B12 deficiency can lead to serious neurological issues, including developmental and epileptic encephalopathy, which is rare in infants.
- A case study presented an 11-month-old girl experiencing severe seizures and developmental delays caused by a mutation in the FUT2 gene that affects vitamin B12 absorption.
- Following diagnosis, she was treated with intramuscular hydroxocobalamin, highlighting the importance of identifying genetic causes of vitamin deficiencies in similar cases.
Ascorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Gadap Road, Karachi, Pakistan.
Article Synopsis
- Photodegradation of drug substances can produce both known and unknown products that interfere with analytical results due to absorption at certain wavelengths.
- The study focuses on improving the accuracy of measurements for methylcobalamin (MC) and hydroxocobalamin by applying linear and non-linear methods to correct for irrelevant absorbances during photolytic degradation involving ascorbic acid (AH).
- Methylcobalamin shows first-order degradation kinetics, with the degradation rate being pH-dependent; it peaks at pH 5.0 when in the presence of ascorbic acid, whereas degradation slows down in more alkaline conditions.
A Brief Overview of the Diagnosis and Treatment of Cobalamin (B12) Deficiency.
Food Nutr Bull
June 2024
University of California Davis, Sacramento, CA, USA.
Background: An increasing number of adult individuals are at risk of vitamin B12 deficiency, either from reduced nutritional intake or impaired gastrointestinal B12 absorption.
Objective: This study aims to review the current best practices for the diagnosis and treatment of individuals with vitamin B12 deficiency.
Methods: A narrative literature review of the diagnosis and treatment of vitamin B12 deficiency.
Investigating the Replacement of Carboxylates with Carboxamides to Modulate the Safety and Efficacy of Platinum(II) Thioether Cyanide Scavengers.
Toxicol Sci
November 2023
Department of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, USA.
Cyanide represents a persistent threat for accidental or malicious misuse due to easy conversion into a toxic gas and access to large quantities through several industries. The high safety index of hydroxocobalamin is a cornerstone quality as a cyanide scavenger. Unfortunately, intravenous infusion of hydroxocobalamin limits the utility in a mass casualty setting.
View Article and Find Full Text PDFClinical, Biochemical and Molecular Features of a Cohort of 8 Patients with Inherited Disorders of Vitamin B12 Metabolism in a Metabolic Reference Center.
Endocr Metab Immune Disord Drug Targets
October 2023
Centro Hospitalar de Lisboa Central Metabolic Diseases Unit, Pediatric Department, Reference Center of Inherited Metabolic Diseases Lisbon Portugal.
Article Synopsis
- Vitamin B12 (cobalamin) metabolism disorders lead to different health issues based on where the metabolic pathway is disrupted, resulting in conditions like combined methylmalonic acidemia and homocystinuria or isolated forms of these diseases.* -
- A study was conducted on patients with these disorders over 23 years, revealing varied clinical presentations, such as severe symptoms at birth or developmental delays, highlighting the diverse impact of these conditions.* -
- The findings align with existing literature on these disorders, emphasizing the need for early diagnosis and tailored treatments, such as betaine or hydroxycobalamin, which were administered to all patients in the study.*
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