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Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel.
Vet Anim Sci
March 2025
Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czech Republic.
In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years.
View Article and Find Full Text PDFDemographic and lifestyle characteristics impact lifetime prevalence of owner-reported intervertebral disc disease: 43,517 companion dogs in the United States.
J Am Vet Med Assoc
January 2025
2Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Objective: Intervertebral disc disease (IVDD) is a debilitating spinal condition that has been well studied among Dachshunds. However, little is known about IVDD prevalence across other dog breeds and associated lifestyle risk factors. The purpose of this study was to identify lifetime prevalence, demographic, and lifestyle factors associated with IVDD among a large population of companion dogs in the US.
View Article and Find Full Text PDFThe first comorbidity networks in companion dogs in the Dog Aging Project.
bioRxiv
December 2024
Division of Public Health Sciences, Fred Hutchinson Cancer Center.
Comorbidity and its association with age are of great interest in geroscience. However, there are few model organisms that are well-suited to study comorbidities that will have high relevance to humans. In this light, we turn our attention to the companion dog.
View Article and Find Full Text PDFExploring risk factors linked to canine lymphoma: a case-control study.
Top Companion Anim Med
January 2025
Vet-OncoNet, Population Studies Department, ICBAS - Instituto de Ciências Biomédicas Abel Salazar-, University of Porto, Rua de Jorge Viterbo Ferreira 228 4050-313, Porto, Portugal; Epidemiology Unit (EPIUnit), Institute of Public Health of the University of Porto (ISPUP), Rua das Taipas 135, 4050-600 Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), Rua das Taipas 135, 4050-600 Porto, Portugal.
Environmental factors, largely influenced by human behavior, account for approximately 80 % of malignant tumors. Risk factors associated with non-Hodgkin's lymphoma (NHL) have been identified in various countries among both humans and domestic animals. This study aimed to investigate potential risk factors for NHL in dogs residing in the district of Porto, Portugal.
View Article and Find Full Text PDFKeratoconjunctivitis sicca in intact Aksaray Malakli breed dogs: Evaluation of 50 cases.
Vet Ophthalmol
December 2024
Faculty of Veterinary Medicine, Department of Biostatistics, Ankara University, Ankara, Turkey.
Article Synopsis
- The study focuses on keratoconjunctivitis sicca (KCS), a condition in dogs that leads to eye damage due to reduced tear production, particularly in Aksaray Malakli breed dogs.
- Researchers evaluated fifty healthy dogs showing signs of eye irritation and used tests to measure tear production and film stability.
- Results indicated that dogs with third eyelid gland prolapse had lower tear production and film stability, highlighting a need for further research to manage KCS in this breed.
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