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Targeted and non-targeted metabolic analysis of chlorpromazine in grass carp as well as the in-silico and metabolomics toxicity assessment.
J Hazard Mater
January 2025
Jiangsu Institute for Food and Drug Control, 6 Beijing West Road, Nanjing 210008, China. Electronic address:
Chlorpromazine (CPZ) is an abused sedative that is extensively metabolized in organisms. However, the metabolic pathway of CPZ in aquatic organisms is still unclear. In this study, CPZ metabolites was analyzed in grass carp exposed to CPZ in the raising water using ultrahigh-performance liquid chromatography coupled with quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS).
View Article and Find Full Text PDFA Case of Bronchopneumonia Presenting With Persistent Hiccups Successfully Treated With Clonazepam and a Traditional Kampo Medicine.
Cureus
December 2024
Division of Nephrology, Toho University Sakura Medical Center, Sakura, JPN.
Persistent hiccups are rare but can serve as an early symptom of underlying conditions, including pulmonary infections and cerebrovascular disorders. This case highlights hiccups as a presenting symptom of bronchopneumonia in a hemodialysis patient and explores the effective use of chlorpromazine and Hange-koboku-to (HKT) as symptomatic therapies. Given the potential association of hiccups with neurological conditions, this case underscores the need for comprehensive diagnostic evaluation.
View Article and Find Full Text PDFAddressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of F-FDG-PET with antipsychotic dose correction.
Schizophrenia (Heidelb)
December 2024
Section of Psychiatry, Laboratory of Molecular and Translational Psychiatry, Unit of Treatment-Resistant Psychiatric Disorders, Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", School of Medicine, Naples Italy, Via Pansini 5, 80131, Naples, Italy.
Few studies using Positron Emission Tomography with F-fluorodeoxyglucose (F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity patterns. Here, we aimed to explore differential patterns of glucose metabolism between patients and controls (CTRL) through a graph theory-based approach and network comparison tests. PET scans with F-FDG were obtained by 70 subjects, 26 with treatment-resistant schizophrenia (TRS), 28 patients responsive to antipsychotics (nTRS), and 16 CTRL.
View Article and Find Full Text PDFDrug-Induced Systemic Lupus Erythematosus: A Rare Presentation of Hydralazine-Induced Lupus.
Cureus
October 2024
Internal Medicine, Arrowhead Regional Medical Center, Colton, USA.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the production of autoantibodies directed against nuclear and cytoplasmic antigens. SLE can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. Hydralazine-induced lupus syndrome was first reported in 1953, and only occurs in 5-10% of patients taking hydralazine.
View Article and Find Full Text PDFThe Legacy of Egas Moniz: Triumphs and Controversies in Medical Innovation.
Cureus
October 2024
Neurology, Emory University, Atlanta, USA.
Article Synopsis
- António Egas Moniz was a pioneering Portuguese neurologist who developed cerebral angiography and the controversial prefrontal leucotomy (lobotomy), earning a Nobel Prize in 1949.
- Lobotomy was initially seen as a breakthrough for severe mental conditions but later faced criticism due to severe side effects, leading to a decline in its use with the introduction of neuroleptics like chlorpromazine.
- Moniz's work sparked important ethical debates about informed consent and the long-term effects of psychiatric procedures, highlighting the need for continuous improvements and ethical standards in mental health treatment.
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