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In Vitro Induction of Hypertrophic Chondrocyte Differentiation of Naïve MSCs by Strain.
Cells
December 2024
AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland.
In the context of bone fractures, the influence of the mechanical environment on the healing outcome is widely accepted, while its influence at the cellular level is still poorly understood. This study explores the influence of mechanical load on naïve mesenchymal stem cell (MSC) differentiation, focusing on hypertrophic chondrocyte differentiation. Unlike primary bone healing, which involves the direct differentiation of MSCs into bone-forming cells, endochondral ossification uses an intermediate cartilage template that remodels into bone.
View Article and Find Full Text PDFSerinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes.
J Cell Physiol
November 2024
Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
The growth plate is the primary site of longitudinal bone growth with chondrocytes playing a pivotal role in endochondral bone development. Chondrocytes undergo a series of differentiation steps, resulting in the formation of a unique hierarchical columnar structure comprising round, proliferating, pre-hypertrophic, and hypertrophic chondrocytes. Pre-hypertrophic chondrocytes, which exist in the transitional stage between proliferating and hypertrophic stages, are a critical cell population in the growth plate.
View Article and Find Full Text PDFRespiratory failure and rhabdomyolysis caused by severe hypokalemia in a young female with hypertension: a rare critical condition in primary aldosteronism.
BMC Urol
October 2024
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: The two classic manifestations of primary aldosteronism are hypertension and hypokalemia. However, acute respiratory failure due to hypokalemia in primary hyperaldosteronism is rare.
Case Presentation: The patient was a 27-year-old female who presented with drowsiness and weakness in all extremities.
Recurrent atrial flutter after radiofrequency ablation for atrial fibrillation in a patient with hypertrophic obstructive cardiomyopathy undergoing repetitive transcoronary ablation of septal hypertrophy.
BMC Cardiovasc Disord
October 2024
Department of Cardiology, Songshan General Hospital, 69 Xingguang Street, Chongqing, 401120, China.
Article Synopsis
- The case study focuses on a 71-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) who experienced multiple arrhythmias and complications, including atrial flutter after her treatments.
- Initially diagnosed with HOCM based on echocardiography, she underwent two transcoronary ablations of septal hypertrophy, with varying success, and later developed atrial fibrillation which required further intervention.
- The findings support that while the treatment of HOCM can be complicated by arrhythmias, a combination of catheter ablation and targeted therapies can lead to positive long-term outcomes for patients.
Dominant stop-loss HNRNPA1 variants in juvenile-onset myopathy.
Muscle Nerve
October 2024
Greg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Introduction/aims: Heterogeneous nuclear ribonucleoprotein A1 is involved in nucleic acid homeostatic functions. The encoding gene HNRNPA1 has been associated with several neuromuscular disorders including an amyotrophic lateral sclerosis-like phenotype, distal hereditary motor neuropathy, multisystem proteinopathy, and various myopathies. We report two unrelated individuals with monoallelic stop loss variants affecting the same codon of HNRNPA1.
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