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Discovery of Novel Thiazolohydrazone Derivatives as an Alternative Option in the Treatment of Zoonotic Toxocara canis: In Vitro and In Silico Evaluation.
Vet Med Sci
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Thiazoles serve as pharmacophores in many molecules that exhibit significant biological activity. This study used in vitro assays and in silico methodologies to identify novel medication candidates for preclinical evaluation of visceral toxocariasis treatment. The objective was to assess the impact of 11 thiazolohydrazone derivative compounds on the larval eggs of Toxocara canis.
View Article and Find Full Text PDFLiver parasites: A global endemic and journey from infestation to intervention.
World J Gastroenterol
January 2025
Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Karachi 75500, Sindh, Pakistan.
Parasites have coexisted with humans throughout history, forming either symbiotic relationships or causing significant morbidity and mortality. The liver is particularly vulnerable to parasitic infections, which can reside in, pass through, or be transported to the liver, leading to severe damage. This editorial explores various parasites that infect the liver, their clinical implications, and diagnostic considerations, as discussed in the article "Parasites of the liver: A global problem?".
View Article and Find Full Text PDFDetection and Characterization of Visceral Anisakid Nematodes in Blue Whiting from Portuguese Waters.
Foods
November 2024
School of Medicine and Biomedical Sciences, Porto University, 4050-313 Porto, Portugal.
Article Synopsis
- This study explores the high prevalence of Anisakid nematodes in blue whiting caught off Portugal, using molecular detection methods like conventional PCR and Sanger sequencing.
- All 50 fish examined were infected, with a breakdown revealing 68.1% of the larvae as one species, marking a first report for another species in these fish, indicating a significant public health risk due to rising raw seafood consumption.
- The findings emphasize the need for better detection methods and safety practices to minimize the risk of anisakidosis, alongside further research on the allergenic potential of these parasites and their environmental distribution.
Presence of Contracaecum sp. larvae in two characiform fish from northeastern Brazil.
Ann Parasitol
December 2024
Universidade Estudual do Maranhão (UEMA). Programa de Pos-Graduação em Ciência Animal (PPGCA). Cidade Universitária Paulo IV, São Luís, 65055-310, São Luís, Maranhão-Brasil
Article Synopsis
- Pygocentrus nattereri and Serrasalmus rhombeus are fish species sold in Maranhão, Brazil, which were studied for parasitic infections.
- Researchers acquired 52 specimens of each species from a market and analyzed their tissues for the presence of parasites.
- The study found nematode larvae in the fish’s internal organs, raising concerns about the risk of zoonotic infections and highlighting the need for public awareness and preventive measures.
The lionfishes: Comparative development of Pterois volitans, Dendrochirus barberi, and D. hemprichi (Scorpaeniformes: Scorpaenidae: Pteroinae) and discrimination of their early life stages from non-pteroine scorpaenid genera in the Western North Atlantic.
Zootaxa
April 2024
El Colegio de la Frontera Sur; Unidad Chetumal Av. Centenario Km 5.5; CP 77014 Chetumal; Quintana Roo; Mexico.
Despite the threat that lionfishes pose to non-native marine ecosystems worldwide, their early life stages (ELS) remain difficult to distinguish from morphologically similar taxa due to inadequate descriptions and poorly defined taxonomic characters. Two members of the Indo-Pacific marine assemblage commonly known as lionfishes, zebrafishes, firefishes, turkeyfishes, and butterfly-cods (Scorpaeniformes: Scorpaenidae: Pteroinae) are invasive in the Western North Atlantic (WNA). Here, we describe the ELS of Pterois volitans, Dendrochirus barberi, and two transforming larvae and an early juvenile of D.
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