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Isolation and Characterization of Lactic Acid Bacteria From "" Having the Ability to Produce α-Glucosidase Inhibitors.
Int J Microbiol
January 2025
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Riau, Pekanbaru, Riau 28293, Indonesia.
Alpha-glucosidase inhibitors are one of the therapies used for treating type 2 diabetes by inhibiting the absorption of carbohydrates in the gastrointestinal tract. In addition to antimicrobial activity, some probiotic species show -glucosidase inhibitor activity, making them potential alternative therapies for type 2 diabetes. This study aimed to characterize probiotics from "," a traditional food from North Sumatra, Indonesia, that exhibit -glucosidase inhibition, potentially useful for type 2 diabetes treatment.
View Article and Find Full Text PDFTransketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation.
Cell Rep
January 2025
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China. Electronic address:
Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM. Here, we show that transketolase (TKT), a metabolic enzyme in the pentose phosphate pathway (PPP), attenuates the chemotherapy sensitivity of glioma cells in a manner independent of catalytic activity. Mechanistically, chemotherapeutic drugs can facilitate the translocation of TKT protein from the cytosol into the nucleus, where TKT physically interacts with XRN2 to regulate the resolution and removal of R-loops.
View Article and Find Full Text PDFDesign, Synthesis, and Herbicidal Activity Study of Novel Pyrazole-Carboxamides as Potential Transketolase Inhibitors.
J Agric Food Chem
January 2025
College of Science, Hebei Agricultural University, Baoding 071001, P. R. China.
Transketolase (TKL; EC 2.2.1.
View Article and Find Full Text PDFSTING exerts antiviral innate immune response by activating pentose phosphate pathway.
Cell Commun Signal
December 2024
School of Life Sciences, Henan University, Kaifeng, Henan Province, China.
Background: The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.
Methods: Metabolomics analysis was used for detecting metabolic alterations in spleens from STING knockout (KO) and wild-type (WT) mice.
Efficient calcium fumarate overproduction from xylose and corncob-derived xylose by engineered strains of Aureobasidium pullulans var. Aubasidani DH177.
Microb Cell Fact
December 2024
College of Marine Life Sciences, Ocean University of China, Yushan Road, No. 5, Qingdao, China.
Article Synopsis
- Xylose, derived from lignocellulose, is a crucial renewable resource for producing valuable bioproducts like fumaric acid; optimizing its conversion is essential.
- The study identified a genetically modified strain (TKL-4) of A. pullulans that effectively uses xylose and corncob-derived xylose to produce calcium fumarate, demonstrating higher yields compared to glucose.
- The TKL-4 strain achieved impressive fermentation results, generating up to 88.5 g/L of calcium fumarate from xylose during a 10-liter fermentation process, showcasing its potential for eco-friendly bioproduct development.
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