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"Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico".
Clin Rheumatol
January 2025
Department of Molecular Biology, Institute of Genomic Science and Medicine, Juárez Avenue 1822 Oriente, 27000, Torreón, Coahuila, México.
Vitamin D deficiency is a public health problem worldwide. Some studies have associated serum vitamin D deficiency with knee osteoarthritis. Additionally, some vitamin D receptor polymorphisms have been linked to knee osteoarthritis.
View Article and Find Full Text PDFProbing the properties of PTEN specific botulinum toxin type E mutants.
J Neural Transm (Vienna)
January 2025
Institut für Zellbiochemie, OE 4310, Medizinische Hochschule Hannover, 30623, Hannover, Germany.
Botulinum neurotoxins (BoNT) are established biopharmaceuticals for neuromuscular and secretory conditions based on their ability to block neurotransmitter release from neurons by proteolyzing specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Recently, a mutant catalytic domain of serotype E (LC/E) exhibiting 16 mutations was reported to cleave the phosphatase and tensin homolog (PTEN). This molecule represents an attractive new target in neurons as several reports support PTEN knockdown as a strategy to stimulate axonal regeneration after injury.
View Article and Find Full Text PDFLLMs, Truth, and Democracy: An Overview of Risks.
Sci Eng Ethics
January 2025
Department of Philosophy, University of Vienna, Vienna, Austria.
While there are many public concerns about the impact of AI on truth and knowledge, especially when it comes to the widespread use of LLMs, there is not much systematic philosophical analysis of these problems and their political implications. This paper aims to assist this effort by providing an overview of some truth-related risks in which LLMs may play a role, including risks concerning hallucination and misinformation, epistemic agency and epistemic bubbles, bullshit and relativism, and epistemic anachronism and epistemic incest, and by offering arguments for why these problems are not only epistemic issues but also raise problems for democracy since they undermine its epistemic basis- especially if we assume democracy theories that go beyond minimalist views. I end with a short reflection on what can be done about these political-epistemic risks, pointing to education as one of the sites for change.
View Article and Find Full Text PDFAssumptions and perceptions of food wasting behavior and intention to reduce food waste in the case of Generation Y and Generation X.
Sci Rep
January 2025
Budapest Business University, 22-24. Diósy L. Str., Budapest, 1165, Hungary.
One of the global problems of our time is food waste that is most significant at the household level. There is a lack of research that focus on the food-wasting behavior of the main breadwinner groups in society, generations Y and X. To fill this gap, the purpose of this study is to analyse the factors that influence the food-wasting behavior of these groups.
View Article and Find Full Text PDFDevelopment of a fixed-order [Formula: see text] controller for a robust P&O-MPPT strategy to control poly-crystalline solar PV energy systems.
Sci Rep
January 2025
Department of Electrical Engineering, College of Engineering, Taif University, Taif, 21944, Saudi Arabia.
This paper presents a novel approach to modeling and controlling a solar photovoltaic conversion system(SPCS) that operates under real-time weather conditions. The primary contribution is the introduction of an uncertain model, which has not been published before, simulating the SPCS's actual functioning. The proposed robust control strategy involves two stages: first, modifying the standard Perturb and Observe (P&O) algorithm to generate an optimal reference voltage using real-time measurements of temperature, solar irradiance, and wind speed.
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