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TAGLN-RhoA/ROCK2-SLC2A3-mediated Mechano-metabolic Axis Promotes Skin Fibrosis.
Int J Biol Sci
January 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, China.
Skin fibrotic diseases are characterized by abnormal fibroblast function and excessive deposition of extracellular matrix. Our previous single-cell sequencing results identified an enriched fibroblast subcluster in skin fibrotic tissues that highly expresses the actin cross-linking cytoskeletal protein Transgelin (TAGLN), which bridges the mechanical environment of tissues and cellular metabolism. Therefore, we aimed to investigate the role of TAGLN in the pathogenesis of skin fibrosis.
View Article and Find Full Text PDFFunctional reconstruction following bilateral amputation of the manus and pes in a cat with frostbite injury.
Can Vet J
January 2025
Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Cormillot); VCA Canada, Guardian Veterinary Centre, 5620 99th Street NW, Edmonton, Alberta T6E 1V2 (Fowler).
This case report describes metacarpophalangeal (MCP)- and metatarsophalangeal (MTP)-level amputation and reconstruction of all 4 paws of a young female domestic shorthair cat. All 4 paws, the ears, and the distal portion of the tail underwent severe frostbite injury resulting in tissue death. Following MCP and MTP amputation, weight-bearing surface reconstruction was achieved using metacarpal and metatarsal paw-pad advancement flaps.
View Article and Find Full Text PDFSingle-cell analysis unveils cell subtypes of acral melanoma cells at the early and late differentiation stages.
J Cancer
January 2025
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhi Zao Ju Rd, Shanghai, 200011, China.
Background: Melanoma, a malignant neoplasm originating from melanocytes, is a form of skin cancer with rapidly increasing global incidence, often exacerbated by UV radiation[1]. Particularly, acral melanoma, characterized by its swift metastasis and poor prognosis, underscores the significance of further research into its heterogeneity. Single-cell sequencing has been widely utilized in the study of tumor heterogeneity; however, research related to melanoma remains to be further refined.
View Article and Find Full Text PDFSkin Rejuvenation Using Autologous Cultured Fibroblast Grafting.
Cureus
December 2024
Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kawasaki, JPN.
Background: Recently, autologous cultured fibroblast and platelet-rich plasma (PRP) therapies have been attempted for skin rejuvenation. Unlike PRP, grafted fibroblasts not only produce connective tissue but also influence the surrounding environment through a paracrine effect. Fibroblast-derived cytokines interact with and are modulated by neighboring tissue-constituting cells.
View Article and Find Full Text PDFA Stepwise Approach to Surgical Decision-making for Lower Eyelid Ectropion: Insights from a Retrospective Study.
Aesthet Surg J
December 2024
Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Background: Cicatricial lower-eyelid ectropion is a serious complication resulting from undesired lower lid blepharoplasty or impaired wound healing. Surgical treatment for ectropion is challenging for oculoplastic surgeons due to the unpredictability of surgical outcome and the difficulty of surgical design.
Objectives: The authors aimed to fully describe the surgical decision-making strategy for cicatricial ectropion, and to potentially enhance treatment outcomes.
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