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Determination of Potential Genotoxic Impurities (Orthophenylene Diamine Dihydrochloride), 4'-Bromomethyl-2-Cyanobiphenyl, 4'(Dibromomethyl)[1,1'-Biphenyl]-2-Carbonitrile in Telmisartan by ESI-MS/MS.
J Chromatogr Sci
March 2023
Department of Pharmacy, Gandhi Institute of Technology and Management, Visakhapatnam 530045, Andhra Pradesh, India.
A sensitive, simple, rapid and robust LC-MS/MS method was developed for the determination of potential genotoxic impurities OPDA HCl (orthophenylene diamine dihydrochloride), bromo OTBN (4'-bromomethyl-2-cyanobiphenyl), dibromo (4'(dibromomethyl)[1,1'-biphenyl]-2-carbonitrile) in Telmisartan by using ESI-MS/MS Technic; the study was performed with gradient elution (time/% mobile phase B: 0/10, 3/10, 30/80, 35/80, 36/10, 40/10). The mobile phase consisted of a mixture of formic acid, methanol and acetonitrile. The buffer was degassed before running at a flow rate of 1.
View Article and Find Full Text PDF[Separation and determination of clenbuterol enantiomers by ultra-performance convergence chromatography].
Se Pu
December 2021
Technical Center for Animal, Plant and Food Inspection and Quarantine, Shanghai Customs, Shanghai 200135, China.
Clenbuterol enantiomers differ greatly in their bioactivities. By optimizing the conditions for chromatographic separation and method validation, ultra-performance convergence chromatography (UPC) was adopted to separate the enantiomers of clenbuterol. Standard solutions of (+)-clenbuterol and (-)-clenbuterol were stored at -18 ℃ for 1, 3, 5, 7, 14, 30, and 60 d, and then, their stability was monitored.
View Article and Find Full Text PDFAnalytical research on the separation and residue of chiral pesticide triadimenol in fruit and vegetable puree.
J Sep Sci
September 2021
Technic Center of Xiamen Customs, Xiamen, P.R. China.
In this paper, a method for the separation of triadimenol stereoisomers using ultra-performance convergence chromatography and an analytical method for the determination of triadimenol stereoisomer residues in pumpkin puree, apple puree, and tomato puree as a supplement for infants are established. Test samples were extracted with acetonitrile and successively purified with graphitized carbon black and Florisil column. Afterward, Acquity Trefoil AMY1 column was adopted for chiral separation of chromatographic column, and gradient elute was carried out with supercritical carbon dioxide-methanol as the mobile phase and with external standard method for quantitation.
View Article and Find Full Text PDFPurification and characterization of aldose reductase from jerboa (Jaculus orientalis) and evaluation of its inhibitory activity by Euphorbia regis-jubae (Webb & Berth) extracts.
Comp Biochem Physiol C Toxicol Pharmacol
June 2021
Laboratoire Santé Et Environnement, Faculté Des Sciences, Université Hassan II-Ain Chock, Casablanca, Morocco.
This study aimed, for the first time, to assess the purification of aldose reductase (AR) in Jaculus orientalis (Dipodidae family) kidney and to evaluate the in vitro aldose reductase inhibitory (ARI) effects of Euphorbia regis-jubae (Euphorbiaceae family) aqueous and hydroethanolic extracts. Initial screening assay of the enzymatic AR activity in different jerboa states (euthermic, prehibernating and hibernating) and tissues (brain, brown adipose tissue, liver and kidneys) was assessed. Then, AR has been purified to homogeneity from the kidneys of prehibernating jerboas by a series of chromatographic technics.
View Article and Find Full Text PDFChemical constituents of the leaves of (Leguminosae).
Nat Prod Res
November 2021
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
The present study deals with the isolation and the characterization of the chemical constituents from the leaves of (Leguminosae). Using various chromatographic techniques (TLC, CC, HPLC), the methanolic extract of the leaves of yielded one new alkaloid () as well as six known compounds amongst which an alkane (), isolated for the first time from a natural product, an ester of fatty acid (), two isocoumarines (), a sterol () and a disaccharide (). Their structures were elucidated using spectroscopic technics including extensive 1-D and 2-D NMR, HR-SM experiments.
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