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Bifidobacterium bifidum 1007478 derived indole-3-lactic acid alleviates NASH via an aromatic hydrocarbon receptor-dependent pathway in zebrafish.
Life Sci
March 2025
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, China. Electronic address:
Aims: This study investigates the potential of Bifidobacterium bifidum 1,007,478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.
Materials And Methods: A zebrafish model of NASH was established by exposure to HFD and fructose. BB478 was administered, and the effects on liver lipid accumulation, oxidative stress, and inflammation were assessed.
[A Case of Successful Hepatic Resection of Hepatocellular Carcinoma Treated with Atezolizumab plus Bevacizumab for Recurrent Liver and Lung Metastases].
Gan To Kagaku Ryoho
February 2025
Dept. of General Surgery, Graduate School of Medicine, Chiba University.
Drug therapy for hepatocellular carcinoma has made remarkable progress in recent years, and surgical resection of tumors that respond well to drug therapy has been performed in some cases. We report a case of hepatocellular carcinoma with hepatopulmonary metastases that was successfully treated with atezolizumab plus bevacizumab and surgically resected. The patient was a 56-year-old man who underwent a posterior segmentectomy and was diagnosed with hepatocellular carcinoma.
View Article and Find Full Text PDF[A Case of Bullous Pemphigoid after Combined Chemotherapy of Durvalumab, Gemcitabine and Cisplatin for Intrahepatic Cholangiocarcinoma].
Gan To Kagaku Ryoho
February 2025
Dept. of Surgery, Kaizuka City Hospital.
The patient is a 66-year-old man. He underwent a total of 9 courses of GCD therapy(gemcitabine+cisplatin+durvalumab)for intrahepatic cholangiocarcinoma with direct invasion of the greater omentum and abdominal wall and surrounding peritoneal dissemination. The tumor had shrunk and was judged to be curative, and laparoscopic hepatic S4a/S5 subsegmentectomy and S6 partial hepatectomy were performed at 8 months after the initial diagnosis.
View Article and Find Full Text PDFThe patient was a 66-year-old man. He came to our hospital because of abdominal discomfort. A CT scan revealed hypovascular tumors of about 70 mm in the S4/5 and 16 mm in the S6 of the liver.
View Article and Find Full Text PDFCaveolin-1 protects against liver injury and lipid accumulation in alcoholic fatty liver via ferroptosis resistance.
Mol Immunol
March 2025
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China; Institute for Liver Diseases of Anhui Medical University, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China. Electronic address:
Alcoholic fatty liver (AFL) is one of the most common chronic liver diseases globally with complex and controversial pathogenesis. Recent evidence suggests that iron overload and lipid peroxidation are risk factors for AFL. Caveolin-1 (CAV1) is an important signal platform that can maintain lipid homeostasis during the development of non-alcoholic fatty liver.
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