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Feasibility of an indocyanine green-hyaluronic acid mixture (LuminoMark™) for targeting suspicious axillary lymph nodes in patients with breast cancer.
BMC Cancer
December 2024
Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
Purpose: During breast cancer surgery, the use of dyes such as indigo carmine, methylene blue, or indocyanine green (ICG) for targeting axillary lymph nodes (ALNs) under ultrasound guidance can result in rapid diffusion, complicated tissue differentiation, and disruption of staining. LuminoMark™, a novel ICG-hyaluronic acid mixture, can provide real-time visualization and minimize dye spread, thereby ensuring a clear surgical field. The aim of our study was to evaluate the efficacy of LuminoMark™ for targeting ALNs in patients with breast cancer.
View Article and Find Full Text PDFInduction treatments with and without addition of one dose anthracycline to all-trans retinoid acid and arsenic in pediatric non-high-risk acute promyelocytic leukemia: study protocol for a randomized controlled trial.
Trials
December 2024
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Article Synopsis
- Acute promyelocytic leukemia (APL) treatment has improved significantly with all-trans retinoic acid (ATRA) and arsenic, but issues like coagulation disorders and differentiation syndrome still pose risks, especially in children.
- A multicenter randomized trial compares the effectiveness of ATRA plus chemotherapy (experimental group) against ATRA alone (control group) in treating pediatric patients with APL, focusing on reducing hyperleukocytosis and complications.
- The goal is to determine whether adding chemotherapy during treatment induction is beneficial in lowering mortality rates among non-high-risk pediatric APL patients.
The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn's Disease.
Adv Ther
December 2024
Kennedy Institute, Translational Gastroenterology Unit and Biomedical Research Centre, University of Oxford, Oxford, UK.
Introduction: Bowel urgency has recently been recognized as a Crohn's disease (CD) symptom that substantially impacts patients' quality of life. The Urgency NRS is a single-item patient-reported outcome measure assessing bowel urgency severity in the past 24 h (0-10 scale). We aimed to evaluate the psychometric properties of the Urgency Numeric Rating Scale (NRS) in adults with moderately to severely active CD and to estimate thresholds for meaningful improvement and bowel urgency remission.
View Article and Find Full Text PDFTryptanthrin Down-Regulates Oncostatin M by Targeting GM-CSF-Mediated PI3K-AKT-NF-κB Axis.
Nutrients
November 2024
Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea.
Background: Oncostatin M (OSM) is involved in several inflammatory responses. Tryptanthrin (TRYP), as a natural alkaloid, is a bioactive compound derived from indigo plants. Objectives/ Methods: The purpose of this study is to investigate the potential inhibitory activity of TRYP on OSM release from neutrophils using neutrophils-like differentiated (d)HL-60 cells and neutrophils from mouse bone marrow.
View Article and Find Full Text PDFMicroplastics in the digestive tract of an endangered cetacean of the Southwest Atlantic Ocean: The franciscana dolphin.
Mar Pollut Bull
January 2025
Instituto de Investigaciones Marinas y Costeras (IIMyC), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Funes 3350, CC1260, B7602AYL Mar del Plata, Argentina; Asociación Naturalista Geselina, Villa Gesell, Argentina.
Article Synopsis
- - This study is the first to analyze the presence of anthropogenic microparticles in franciscana dolphins, the most endangered cetaceans in the Southwest Atlantic Ocean, using samples from ten female dolphins collected between 2013 and 2023.
- - Analysis of the intestinal content and wall tissues revealed that all samples contained anthropogenic particles, primarily in the form of fibers, with various types of polymers like polyester and polypropylene identified through advanced spectroscopic techniques.
- - The research indicated differences in the types and colors of microplastics found in various sections of the dolphin's intestines, highlighting the extent of microplastic absorption in these endangered animals.
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