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Actinomycetes: Treasure trove for discovering novel antibiotic candidates.
Eur J Med Chem
January 2025
School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China. Electronic address:
Actinomycetes are an important source of secondary metabolites such as antibiotics and other active natural products. Many well-known antibiotics, such as streptomycin, oxytetracycline, and tetracycline, are produced by actinomycetes. Different types of antibiotics have distinct mechanisms of action against microorganisms: inhibit protein synthesis, inhibit nucleic acid synthesis, or inhibit cell wall synthesis.
View Article and Find Full Text PDFPotential of lavender essential oil to inhibit tetracycline resistance and modulate gut microbiota in black soldier fly larvae.
J Hazard Mater
January 2025
Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang 561113, China; Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry, Guizhou Medical University, Guiyang 561113, China. Electronic address:
The misuse of tetracycline in livestock farming leads to environmental residues that promote the proliferation of antibiotic resistance genes (ARGs), particularly tetracycline resistance (tet) genes. Black soldier fly (BSF) larvae, used for organic waste bioconversion, may carry tetracycline residues in their guts, raising concerns about ARG spread. To address this issue, plant-derived additives such as lavender essential oil (LEO) have been explored as alternative antibiotics.
View Article and Find Full Text PDFOxytetracycline and Florfenicol Association Affects Zebrafish Larvae Behavioral Repertoire.
Arch Environ Contam Toxicol
January 2025
Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Oxytetracycline (OTC) and Florfenicol (FF) are prevalent antibiotics choices in both fish production and livestock farming. A comprehensive understanding of their effects is paramount for effective control of their use and for elucidating their physiological and pharmacological implications. In our investigation, zebrafish larvae were subjected to varying concentrations of OTC, FF or a combination of OTC + FF during 96 h.
View Article and Find Full Text PDFRemoval of Antibiotics in Breeding Wastewater Tailwater Using Microalgae-Based Process.
Bull Environ Contam Toxicol
January 2025
Key Laboratory of Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing, 400045, China.
Ciprofloxacin (CIP) and oxytetracycline (OTC) are commonly detected antibiotic species in breeding wastewater, and microalgae-based antibiotic treatment technology is an environmentally friendly and cost-effective method for its removal. This study evaluated the effects of CIP and OTC on Scenedesmus sp. in the breeding wastewater tailwater and the removal mechanisms of antibiotics.
View Article and Find Full Text PDF24-epibrassinolide regulates oxytetracycline-induced phytotoxicity and its detoxification mechanism.
Ecotoxicol Environ Saf
January 2025
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China. Electronic address:
Oxytetracycline (OTC), a crop-absorbable antibiotic, poses a health risk to humans through the food chain. Conversely, 24-epibrassinolide (EBL), a plant growth hormone, mitigates the toxic effects of various pollutants on plants. However, the mechanism by which exogenous EBL affects the growth of rape seedlings exposed to OTC remains largely unknown.
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