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Olfactory training affects the correlation between brain structure and functional connectivity.

Neuroradiol J

December 2024

Finetech in Medicine Research Center, Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Purpose: and background: Neuroimaging studies have increasingly found functional connectivity (FC) changes and structural cortical abnormalities in patients with post-traumatic anosmia (PTA). Training and repeated exposure to odorants lead to enhanced olfactory capability. This study is conducted to investigate the correlations between FC and cortical thickness on the olfaction-related regions of the brain in PTA after olfactory training (OT).

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COVID-19 is associated with neuropsychiatric symptoms, such as anosmia, anxiety, depression, stress-related reactions, and psychoses. The illness can cause persistent cognitive impairment and "brain fog", suggesting chronic brain involvement. Clinical entities of ongoing symptomatic COVID-19 and Post COVID Syndrome (PCS) mainly present neuropsychiatric symptoms such as dysgeusia, headache, fatigue, anxiety, depression, sleep disturbances, and post-traumatic stress disorder.

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The COVID-19 pandemic has led to long-lasting consequences for workers leading to what has been termed a "psychological pandemic". Some categories, such as healthcare workers (HCWs), are considered high risk due to factors such as increased exposure and stressful working conditions. In this study, we investigate whether levels of posttraumatic stress symptoms and COVID-19-related fear (IES-6 and PSI-4) are associated with illness severity in a sample of 318 infected HCWs in Italy.

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Article Synopsis
  • * The study involved 736 participants screened, with 402 completing detailed cognitive and clinical assessments, revealing that those with CI experienced more severe mental health issues and poorer overall functioning compared to those without cognitive impairment.
  • * Additionally, 45% of participants demonstrated cognitive deficits in areas like attention and memory, and worse cognitive functioning was associated with higher LDH blood levels, suggesting the need for regular cognitive assessments and possible training programs for affected individuals.
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Objective: To analyse variations in the n-butanol threshold and odour identification scores of the Connecticut Chemosensory Clinical Research Centre test in various grades of olfactory dysfunction and in different nasal conditions leading to olfactory loss.

Method: Retrospective observational study.

Results: All grades of olfactory dysfunction were predominantly noted among males.

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