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Simultaneous Determination of 12 Disinfection By-Products in Fish Muscles by Solvent Extraction Coupled With Gas Chromatography Equipped With an Electron Capture Detector.
J Sep Sci
December 2024
Key Laboratory of Yangtze River Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, the People's Republic of China.
Disinfection by-products (DBPs) have received considerable focus due to potential teratogenic, carcinogenic, and mutagenic effects; however, there is an evident gap in the availability of analytical methodologies for the simultaneous determination of DBPs in fish, especially iodinated DBPs. This paper developed an innovative analytical method for the simultaneous determination of 12 DBPs, including four trihalomethanes (THMs), three haloacetonitriles, and five iodinated THMs (I-THMs), in fish muscle, utilizing solvent extraction followed by gas chromatography with electron capture detection. The method incorporates tert-butyl methyl ether as an extraction solvent, performing efficient vortex mixing, extraction, and centrifugation under reduced temperature conditions to facilitate the processing of physically disrupted fish tissues.
View Article and Find Full Text PDFStudy on identification of diagnostic biomarkers in serum for papillary thyroid cancer in different iodine nutrition regions.
Biomarkers
December 2024
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
Background: At present, there is a lack of efficient biomarkers for the diagnosis of thyroid cancer, and the influence of natural factors such as high iodine exposure on the expression of biomarkers remains unclear.
Methods: Serum samples from papillary thyroid cancer (PTC) and non-cancer controls matched 1:1 in different iodine nutritional regions were analyzed metabolomically using an ultra-high performance liquid chromatography-Orbitrap Exploris mass spectrometry (UHPLC-OE-MS) platform. Then the data were randomly divided into training and test sets in a 1:1 ratio according to the different iodine nutritional regions and different PTC status.
Gas Chromatography-Tandem Mass Spectrometry Method for Analyses of Iodoform and Diiodomethane in Multiple Biological Matrices from Dairy Cattle.
J Agric Food Chem
January 2025
Department of Animal and Veterinary Sciences, Research Centre Foulum, Aarhus University Viborg, Tjele 8830, Denmark.
A quantitative method was developed and validated to analyze iodoform and its potential metabolite, diiodomethane, in biological fluids from dairy cows, including rumen fluid, duodenal fluid, blood serum, milk, and urine, using liquid-liquid extraction (LLE) and GC-MS/MS. The method showed no matrix effects across different samples, recoveries of spiked samples between 70 and 120%, and relative standard deviations (RSD%) ranging from 0.7 to 14%.
View Article and Find Full Text PDFRevolutionary ZVI-Entrapped Sol-Gel Silica Matrices: Efficient Catalytic Reduction of High-Concentration Halo-Organic Compounds-Addressing Bromoacetic Acid Contamination in Industrial Wastewaters.
Gels
November 2024
Chemical Engineering Department and The Radical Research Center, Ariel University, Ariel 4070000, Israel.
The de-halogenation of highly concentrated halo-organic compounds using Zero Valent Iron entrapped in silica matrices as a catalyst was investigated. This study aimed to evaluate the effectiveness of the Zero Valent Iron-entrapped organically modified silica matrices in transforming highly concentrated hazardous halogenated compounds into environmentally benign materials in the presence of BH. The Zero Valent Iron-entrapped silica gel matrices were synthesized using the sol-gel method.
View Article and Find Full Text PDFA Sensitive Radioimmunoassay for T3 and T4 Determinations in Plasma and Tissues.
Methods Mol Biol
November 2024
Laboratory of Thyroid Hormones and Central Nervous System, Department of Neurological Diseases and Aging, Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
This chapter details protocols for determining plasma thyroid hormone (TH) levels and tissue TH content by competitive radioimmunoassays (RIAs). These protocols include: an initial test of the chromatographic performance, isotopic labeling to produce high activity I-T3 and I-T4, free iodide estimation of the labeled products, purification of tracers from iodide by paper electrophoresis, extraction of THs from plasma and tissue samples, and the RIA procedures. The RIA involves the competition between radioactive labeled and unlabeled hormones for specific antibody binding, and due to its high sensitivity is capable of detecting a minimum of 2.
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