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TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall.
Dermatopathology (Basel)
July 2024
Department of Anatomic Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Article Synopsis
- The study investigates TRPS1 immunoreactivity in various cutaneous mesenchymal neoplasms and tumors of uncertain differentiation, highlighting gaps in existing research.
- Out of 135 analyzed cases, TRPS1 was found to be highly prevalent in dermatofibromas and atypical fibroxanthomas, while being less common in vascular tumors and absent in certain tumors like perineuriomas.
- The findings indicate significant differences in TRPS1 expression levels between AFXs and other tumor types, although it shows limited effectiveness in differentiating between atypical fibroxanthomas and sarcomatoid squamous cell carcinoma.
A challenging diagnosis of dermatofibrosarcoma protuberans of the middle finger in an infant: A case report.
Int J Surg Case Rep
July 2024
Damascus university, Faculty of Medicine, Damascus, Syrian Arab Republic; Stemosis for Scientific Research, Damascus, Syrian Arab Republic.
Article Synopsis
- Dermatofibrosarcoma protuberans (DFSP) is a rare type of cancer, mainly affecting adults, but can occur in infants, making diagnosis and treatment challenging due to its slow-growing nature.
- An 8-month-old infant was initially misdiagnosed with a dermatofibroma; after multiple surgeries, DFSP was confirmed, highlighting the importance of accurate early diagnosis.
- Early detection and careful surgical removal with clear margins are crucial for managing DFSP, especially in young patients, to prevent recurrence and improve outcomes.
Ex Vivo Confocal Laser Scanning Microscopy in Rare Skin Diseases.
Cancers (Basel)
April 2024
Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, 80337 Munich, Germany.
Article Synopsis
- Ex vivo confocal laser scanning microscopy (CLSM) has been primarily used for common skin diseases, with limited exploration of its effectiveness in rare skin tumors and inflammatory conditions.
- The study involved imaging 50 tissue samples, including rare disorders, to evaluate diagnostic efficacy and involved three blinded investigators assessing the images for distinct features.
- Results indicated that imaging expertise significantly improved diagnostic accuracy, with the trained dermatopathologists achieving up to 92% agreement with standard dermatohistopathology, showcasing CLSM's potential as a valuable tool for identifying rare skin disorders.
Utility of LEF1 to differentiate desmoid fibromatosis from its histologic mimics.
Virchows Arch
May 2024
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, WRN2, 55 Fruit St, Boston, MA, 02114, USA.
Diagnosis of desmoid-type fibromatosis (DF) may be challenging on biopsy due to morphologic overlap with reactive fibrosis (scar) and other uniform spindle cell neoplasms. Evaluation of nuclear β-catenin, a surrogate of Wnt pathway activation, is often difficult in DF due to weak nuclear expression and high background membranous/cytoplasmic staining. Lymphoid enhancer-factor 1 (LEF1) is a recently characterized effector partner of β-catenin which activates the transcription of target genes.
View Article and Find Full Text PDF"Unusual Presentation of Epitheloid Dermatofibroma- Rare Case Report".
Indian J Otolaryngol Head Neck Surg
February 2024
K.D. Parvadiya Multispeciality Hospital, Atkot, Gujarat 360040 India.
Dermatofibroma is a commonly occurring cutaneous entity usually centered within the skin's dermis. Dermatofibromas are referred to as benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytoma. These mesenchymal cell lesions of the dermis clinically are firm subcutaneous nodules that occur on the extremities in the vast majority of cases and may or may not be associated with overlying skin changes.
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