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Validation of a suspicion index to identify patients at risk for hereditary angioedema.
J Allergy Clin Immunol Glob
February 2023
University of California, San Diego, Calif.
Background: Hereditary angioedema (HAE) is a genetic condition characterized by dysregulation of the contact (kallikrein-bradykinin) pathway, leading to recurrent episodes of angioedema.
Objective: This project sought to determine whether a suspicion index screening tool using electronic health record (EHR) data can identify patients with an increased likelihood of a diagnosis of HAE.
Methods: A suspicion index screening tool for HAE was created and validated by using known patients with HAE from the medical literature as well as positive and negative controls from HAE-focused centers.
Temporal Trends in the Use of Computed Tomographic Pulmonary Angiography for Suspected Pulmonary Embolism in the Emergency Department : A Retrospective Analysis.
Ann Intern Med
June 2023
Department of Clinical Pharmacology and Clinical Research Platform Paris-East (URCEST-CRC-CRB), Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France (M.C., A.A.).
Article Synopsis
- - Validated clinical decision rules aimed at reducing unnecessary use of computed tomographic pulmonary angiography (CTPA) in emergency departments (EDs) for suspected pulmonary embolism (PE) were analyzed to observe changes in CTPA usage over time.
- - A retrospective study across 26 European EDs examined nearly 9,000 CTPAs performed between January 2015 and December 2019, revealing significant increases in CTPA usage and diagnosed PEs, particularly among low-risk patients.
- - The findings indicated a trend toward more frequent CTPA use and a higher diagnosis rate of PEs despite efforts to limit unnecessary imaging, highlighting the need for ongoing assessment of clinical decision rules in practice.
In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant.
J Photochem Photobiol B
February 2023
Cancer Research Center, Jiangxi University of Chinese Medicine, Nanchang 330004, China; Jiangxi Engineering Research Center for Translational Cancer Technology, Nanchang 330004, China. Electronic address:
Cancer molecular imaging using specific probes designed to identify target proteins in cancer is a powerful tool to guide therapeutic selection, patient management, and follow-up. We demonstrated that icatibant may be used as a targeting probe for the significantly upregulated bradykinin B2R in colorectal cancer (CRC). Icatibant-based probes with high affinity towards bradykinin B2R were identified.
View Article and Find Full Text PDFDigital Clubbing in Hereditary Hemorrhagic Telangiectasia/Juvenile Polyposis Syndrome.
Acta Dermatovenerol Croat
April 2021
Anna Mrzljak MD, PhD, Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, Kišpatićeva 12, Zagreb; School of Medicine, University of Zagreb, , Salata 3b, 10000 Zagreb, Croatia;
Article Synopsis
- * The condition can coexist with juvenile polyposis syndrome (JPS), complicating treatment and increasing health risks, but often only leads to mild physical symptoms like digital clubbing.
- * A case study of a 15-year-old girl highlighted her diagnosis of HHT and JPS, revealing challenges such as recurrent gastrointestinal bleeding and the absence of typical skin findings (telangiectasias) usually seen in HHT patients.
Unilateral orolingual angioedema in a patient with sarcoidosis after intravenous thrombolysis due to acute stroke without improvement after treatment with icatibant.
BMJ Case Rep
December 2020
Neurology, Cantonal Hospital of Baden, Baden, Aargau, Switzerland
A potential complication after intravenous administration of recombinant tissue plasminogen activators (rtPAs) for thrombolysis in acute ischaemic stroke is orolingual angioedema, with an incidence of 0.4%-7.9%.
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