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Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors.
Eur J Endocrinol
January 2025
Department of Internal Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Objective: The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) and gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Methods: We evaluated the effects of estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), and testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n = 12), performed next-generation sequencing and immunohistochemical hormone receptor analysis in patient-derived PPGL tumor tissues (n = 36).
Results: In PPGLs, estradiol and progesterone (1 µm) demonstrated overall significant antitumor effects with the strongest efficacy in PPGLs with NF1 (cluster 2) pathogenic variants.
Safety of electroconvulsive therapy in the context of physiological and medical complexity: A state-of-the art review.
PCN Rep
March 2025
Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia.
Medical contraindications and complications pose challenges for electroconvulsive therapy (ECT). Most published reports are scattered across various physiological systems and individual disease conditions. This review aimed to evaluate the literature on physiological and medical complexities during ECT and discuss risk mitigation strategies in a comprehensive review.
View Article and Find Full Text PDFUnmasking the Hidden Threat: A Case Report of the Anesthetic Management of a Catecholamine-Secreting Tumor in Pregnancy.
Cureus
October 2024
Anesthesiology, Unidade Local de Saúde do Alto Ave, Guimarães, PRT.
Article Synopsis
- - Catecholamine-secreting tumors (CSTs) are rare but can pose serious risks for both mother and baby during pregnancy, often complicating diagnosis due to similarities with conditions like preeclampsia.
- - A case study of a 24-year-old pregnant woman revealed that timely management of hypertension and surgical intervention were crucial; she was diagnosed with a CST at 27 weeks, managed with medication, and had an elective cesarean at 32 weeks, delivering a healthy baby.
- - Successful outcomes depend on early diagnosis, tailored medical and surgical approaches, and teamwork among various healthcare specialists, emphasizing the need for heightened awareness of CSTs in hypertensive pregnant patients.
[Paraganglioma and pregnancy: A thrilling urination story].
Gynecol Obstet Fertil Senol
January 2025
Gynécologie-obstétrique et médecine de la reproduction, CHU de Caen, avenue de la Côte de Nacre, 14000 Caen, France; UFR médecine Caen, rue des Rochambelles, 14000 Caen, France.
Objectives: Carrying out a pregnancy to term in a patient with a paraganglioma or pheochromocytoma (PPGL) results from a multidisciplinary challenge. The objective was to compare our therapeutic attitude with the existing literature and to identify optimal treatment.
Methods: Description of a case of paraganglioma treated during pregnancy at the University Hospital Center of Caen (France) in 2024 and comparison with the literature.
Update on clinical characteristics in the evaluation of phaeochromocytoma and paraganglioma.
Best Pract Res Clin Endocrinol Metab
December 2024
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Article Synopsis
- Pheochromocytomas and sympathetic paragangliomas (PPGL) are rare neuroendocrine tumors that can be difficult to diagnose due to their varied symptoms, which often resemble other conditions.
- These tumors have shifted from being diagnosed mostly after death to being discovered incidentally or through screening, thanks to improved clinical scoring systems that help identify at-risk patients.
- Management of PPGL has advanced with new treatment options, but it remains a significant concern in pregnant patients due to high mortality risks, emphasizing the need for increased awareness and prompt diagnosis.
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