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Xenon anaesthesia is associated with a reduction in frontal electroencephalogram peak alpha frequency.
BJA Open
December 2024
Department of Anaesthesia, Waikato Clinical School, Waikato Hospital, University of Auckland, New Zealand.
Background: Administration of conventional anaesthetic agents is associated with changes in electroencephalogram (EEG) oscillatory dynamics, including a reduction in the peak alpha frequency. Computational models of neurones can reproduce such phenomena and are valuable tools for investigating their underlying mechanisms. We hypothesised that EEG data acquired during xenon anaesthesia in humans would show similar changes in peak alpha frequency and that computational neuronal models of recognised cellular actions of xenon would be consistent with the observed changes.
View Article and Find Full Text PDFThe Role of GABA Receptors in Anesthesia and Sedation: An Updated Review.
CNS Drugs
January 2025
Department of Anesthesiology, Jefferson Surgical Center Endoscopy, Sidney Kimmel Medical College, Jefferson Health, 111 S 11th Street, #7132, Philadelphia, PA, 19107, USA.
GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. They are formed by 5 subunits out of 19 various subunits: α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3. Two main subtypes of GABA receptors have been identified, namely GABAA and GABAB.
View Article and Find Full Text PDFA narrative review of gas separation and conservation technologies during xenon anesthesia.
Med Gas Res
March 2025
Department of Anesthesia and Acute Pain Medicine, St. Vincent's Hospital Melbourne, Melbourne, Australia.
Xenon gas has significant advantages over conventional general anesthetic agents but its use has been limited by the cost associated with its production. Xenon also has significant potential for medical use in the treatment of acquired brain injuries and for mental health disorders. As the demand for xenon gas from other industries increases, the costs associated with its medical use are only likely to increase.
View Article and Find Full Text PDFPhotosensitivity-Induced Pediatric Rash Following Surgery: A Case Study.
Cureus
September 2024
Anesthesiology, University of Texas Medical Branch, Galveston, USA.
Photosensitivity is characterized by an abnormal skin reaction to light that causes various adverse skin reactions such as blistering, redness, and inflammation. Photosensitivity may also depend on the wavelength of the light as minor changes affect different layers of the skin. During surgical procedures, many different types of light are used with a range of wavelengths.
View Article and Find Full Text PDFAnaesthetics disrupt complex I-linked respiration and reverse the ATP synthase.
Biochim Biophys Acta Bioenerg
January 2025
Centre for Life's Origins and Evolution (CLOE), Department of Genetics, Evolution and Environment, University College London, United Kingdom of Great Britain and Northern Ireland. Electronic address:
The mechanism of volatile general anaesthetics has long been a mystery. Anaesthetics have no structural motifs in common, beyond lipid solubility, yet all exert a similar effect. The fact that the inert gas xenon is an anaesthetic suggests their common mechanism might relate to physical rather than chemical properties.
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