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Objective: Skeletal muscle fat infiltration (myosteatosis) increases with age and is an emerging risk factor for dementia. We aimed to determine the association between myosteatosis and cognitive decline among middle-aged White and Black Americans.
Methods: Data were on men (n=1,080; 41.
Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems, and utilized self-reported measures of fatigue. We tested the association between energy metabolism in the brain and an objective measure of fatigability in the Study of Muscle, Mobility and Aging (N=119, age 76.8±4.
View Article and Find Full Text PDFVertical Mandibular Asymmetry in Unilateral Cleft Lip and Palate: A Comparative Analysis With Skeletal Class III and Class I Malocclusions.
Cureus
December 2024
Department of Orthodontics and Dentofacial Orthopedics, Government Dental College, Thiruvananthapuram, Thiruvananthapuram, IND.
Introduction Unilateral cleft lip and palate (UCLP) often leads to maxillary hypoplasia and skeletal Class III malocclusion, with conflicting evidence on mandibular asymmetry. This study evaluated vertical mandibular asymmetry in UCLP patients, comparing them with non-cleft individuals having skeletal Class III and Class I malocclusions. Methods Mandibular asymmetry was evaluated using orthopantomograms (OPGs) from 90 subjects divided into three groups of 30 each: UCLP group, non-cleft skeletal Class III, and non-cleft skeletal Class I.
View Article and Find Full Text PDFIntegrating deep learning and machine learning for improved CKD-related cortical bone assessment in HRpQCT images: A pilot study.
Bone Rep
March 2025
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States of America.
High resolution peripheral quantitative computed tomography (HRpQCT) offers detailed bone geometry and microarchitecture assessment, including cortical porosity, but assessing chronic kidney disease (CKD) bone images remains challenging. This proof-of-concept study merges deep learning and machine learning to 1) improve automatic segmentation, particularly in cases with severe cortical porosity and trabeculated endosteal surfaces, and 2) maximize image information using machine learning feature extraction to classify CKD-related skeletal abnormalities, surpassing conventional DXA and CT measures. We included 30 individuals (20 non-CKD, 10 stage 3 to 5D CKD) who underwent HRpQCT of the distal and diaphyseal radius and tibia and contributed data to develop and validate four different AI models for each anatomical site.
View Article and Find Full Text PDFDentoalveolar and Skeletal Effects of an Anterior Open Bite Treatment Protocol Using Zygomatic Anchorage.
Orthod Craniofac Res
January 2025
Department of Orthodontics, Dental School, Okan University, Istanbul, Turkey.
Objective: Primary aim was to analyse dentoalveolar and skeletal effects induced by an anterior open bite (AOB) treatment protocol for intrusion of maxillary buccal segment. Secondary aim was to investigate whether a subsequent change occurred in hyoid position.
Materials And Methods: Study group included 28 non-growing subjects treated in academic setting for correction of AOB.
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