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Diagnostic performance of parasitological, immunological and molecular tests for the diagnosis of Schistosoma mansoni infection in a community of low transmission in Venezuela.
Acta Trop
April 2020
Laboratorio de Investigaciones en Bilharzia, Departamento de Parasitología, Facultad de Ciencias de la Salud, Universidad de Carabobo, Carabobo, Sede Valencia, Venezuela. Electronic address:
Article Synopsis
- In Venezuela, schistosomiasis has low transmission rates, complicating the differentiation between past and present infections due to the lack of specificity in immunological tests.
- The study aimed to evaluate the effectiveness of various diagnostic methods for Schistosoma mansoni in a rural, endemic community, including Kato-Katz, COPT, ELISA variations, and PCR.
- Results indicated that ELISA-SEA was the most reliable for diagnosing infections, while PCR on feces was best for recent cases; overall, a significant prevalence of 33.8% was found in this low-transmission setting.
Proteomic and immunomic analysis of Schistosoma mekongi egg proteins.
Exp Parasitol
August 2018
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. Electronic address:
Schistosomiasis remains a global health problem. In the Mekong river basin, approximately 80,000 people are at risk of infection by Schistosoma mekongi. The parasite's eggs become entrapped in the host's organs and induce massive inflammation, contributing to the pathogenesis of schistosomiasis.
View Article and Find Full Text PDFComparative Study of the Accuracy of Different Techniques for the Laboratory Diagnosis of Schistosomiasis Mansoni in Areas of Low Endemicity in Barra Mansa City, Rio de Janeiro State, Brazil.
Biomed Res Int
August 2016
Department of Infectious and Parasitic Diseases and Laboratory of Immunopathology of Schistosomiasis (LIM-06), School of Medicine, University of São Paulo, 05403-000 São Paulo, SP, Brazil.
Schistosomiasis constitutes a major public health problem, with an estimated 200 million people infected worldwide. Many areas of Brazil show low endemicity of schistosomiasis, and the current standard parasitological techniques are not sufficiently sensitive to detect the low-level helminth infections common in areas of low endemicity (ALEs). This study compared the Kato-Katz (KK); Hoffman, Pons, and Janer (HH); enzyme-linked immunosorbent assay- (ELISA-) IgG and ELISA-IgM; indirect immunofluorescence technique (IFT-IgM); and qPCR techniques for schistosomiasis detection in serum and fecal samples, using the circumoval precipitin test (COPT) as reference.
View Article and Find Full Text PDFLong-term effect of mass chemotherapy, transmission and risk factors for Schistosoma mansoni infection in very low endemic communities of Venezuela.
Acta Trop
December 2014
Department of Parasitology, Faculty of Health Sciences, Universidad de Carabobo, Valencia, Venezuela. Electronic address:
The prevalence of Schistosoma mansoni infection in Venezuela has changed from high to low due mostly to successful control activities, including mass chemotherapy and molluscicide applications. This study examined the impact of mass chemotherapy on S. mansoni transmission and risk factors for infection 12 years after administration of praziquantel in Venezuela.
View Article and Find Full Text PDFDetection of Schistosoma mansoni infection by TaqMan® Real-Time PCR in a hamster model.
Exp Parasitol
August 2014
Department of Infectious and Parasitic Diseases and Laboratory of Medical Investigation 6, Faculdade de Medicina da Universidade de São Paulo, Brazil.
An experimental study in hamsters was performed to evaluate the capability for detecting Schistosoma mansoni DNA in serum and fecal samples during the pre and post-egg-laying periods of infection using TaqMan® Real-Time PCR system (qPCR), was compared with the circumoval precipitin test (COPT) and the Kato-Katz technique, especially among individuals with low parasitic burden. Twenty-four hamsters were infected with cercariae. Three hamsters were sacrificed per week under anesthesia, from 7 days post infection (DPI) up to 56 DPI.
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