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Zoledronic acid relieves steroid-induced avascular necrosis of femoral head via inhibiting FOXD3 mediated ANXA2 transcriptional activation.
Bone
November 2024
Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, PR China. Electronic address:
Background: Zoledronic acid (ZOL) is a type of bisphosphonate with good therapeutic effects on orthopaedic diseases. However, the pharmacological functions of ZOL on steroid-induced avascular necrosis of femoral head (SANFH) and the underlying mechanism remain unclear, which deserve further research.
Methods: SANFH models both in vivo and in vitro were established by dexamethasone (Dex) stimulation.
Study on the anti-inflammatory mechanism of moxibustion in rheumatoid arthritis in rats based on phospholipaseA2 signaling inhibition by Annexin 1.
J Tradit Chin Med
August 2024
Department of Acupuncture-Moxibustion and Tuina, the Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Article Synopsis
- The study aimed to evaluate the anti-inflammatory effects of moxibustion on rheumatoid arthritis (RA) by analyzing its impact on Annexin 1 expression and the phospholipase A2 signaling pathway.
- Thirty male rats were divided into five groups to test various treatments, including moxibustion and Annexin 1 interference, following the induction of RA with Freund's complete adjuvant.
- Results indicated that moxibustion enhanced Annexin 1 levels, reduced inflammation, and positively influenced various inflammatory markers in the rats, suggesting its potential therapeutic role in RA.
Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells.
Sci Rep
July 2024
Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Science, Linköping University, 581 83, Linköping, Sweden.
Inflammation, corticosteroids, and loading all affect tendon healing, with an interaction between them. However, underlying mechanisms behind the effect of corticosteroids and the interaction with loading remain unclear. The aim of this study was to investigate the role of dexamethasone during tendon healing, including specific effects on tendon cells.
View Article and Find Full Text PDFCracking the code of Annexin A1-mediated chemoresistance.
Biochem Biophys Res Commun
September 2024
Department of Pharmacology, Faculty of Medicine, University Malaya, 50603, Kuala, Lumpur, Malaysia; School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, 246 Clayton Road, Clayton, VIC, 3168, Australia. Electronic address:
The annexin superfamily protein, Annexin A1, initially recognized for its glucocorticoid-induced phospholipase A2-inhibitory activities, has emerged as a crucial player in diverse cellular processes, including cancer. This review explores the multifaceted roles of Anx-A1 in cancer chemoresistance, an area largely unexplored. Anx-A1's involvement in anti-inflammatory processes, its complex phosphorylation patterns, and its context-dependent switch from anti-to pro-inflammatory in cancer highlights its intricate regulatory mechanisms.
View Article and Find Full Text PDFThe pro-resolving mediator, annexin A1 regulates blood pressure, and age-associated changes in cardiovascular function and remodeling.
FASEB J
February 2024
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Aging is associated with chronic, low-level inflammation which may contribute to cardiovascular pathologies such as hypertension and atherosclerosis. This chronic inflammation may be opposed by endogenous mechanisms to limit inflammation, for example, by the actions of annexin A1 (ANXA1), an endogenous glucocorticoid-regulated protein that has anti-inflammatory and pro-resolving activity. We hypothesized the pro-resolving mediator ANXA1 protects against age-induced changes in blood pressure (BP), cardiovascular structure and function, and cardiac senescence.
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