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Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.
PLoS One
January 2025
Dept. of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, United States of America.
Opioid dependence is defined by an aversive withdrawal syndrome upon drug cessation that can motivate continued drug-taking, development of opioid use disorder, and precipitate relapse. An understudied but common opioid withdrawal symptom is disrupted sleep, reported as both insomnia and daytime sleepiness. Despite the prevalence and severity of sleep disturbances during opioid withdrawal, there is a gap in our understanding of their interactions.
View Article and Find Full Text PDFArtificial intelligence applied in identifying left ventricular walls in myocardial perfusion scintigraphy images: Pilot study.
PLoS One
January 2025
Electrical, Mechanical & Computer Engineering School, Federal University of Goias, Goiania, Brazil.
This paper proposes the use of artificial intelligence techniques, specifically the nnU-Net convolutional neural network, to improve the identification of left ventricular walls in images of myocardial perfusion scintigraphy, with the objective of improving the diagnosis and treatment of coronary artery disease. The methodology included data collection in a clinical environment, followed by data preparation and analysis using the 3D Slicer Platform for manual segmentation, and subsequently, the application of artificial intelligence models for automated segmentation, focusing on the efficiency of identifying the walls of the left ventricular. A total of 83 clinical routine exams were collected, each exam containing 50 slices, which is 4,150 images.
View Article and Find Full Text PDFA Dual-Channel Fluorescence Probe for Early Diagnosis and Treatment Monitoring of Acute Kidney Injury by Detecting HOCl and Cys with Different Fluorescence Signals.
Anal Chem
January 2025
State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu Lanzhou 730000, China.
The pathogenesis of acute kidney injury (AKI) is a multifaceted process involving various mechanisms, with oxidative stress playing a crucial role in its development. Hypochlorite (HOCl) and cysteine (Cys) are indicators of oxidative stress in AKI pathophysiology, directly reflecting the degree of oxidative stress and disease severity. However, their exact mechanism of action in AKI pathophysiology remains unknown.
View Article and Find Full Text PDFExperiences of Patients and Families Living with Krabbe Disease.
J Patient Exp
January 2025
Division of Health Science, Child Healthcare and Genetic Science Laboratory, Osaka University Graduate School of Medicine, Suita, Japan.
The challenges faced by patients with Krabbe disease remain unelucidated. This study aimed to identify these challenges and facilitate the development of methods for assessing the quality of life. This qualitative descriptive study used in-person or online semistructured interviews from March to December 2022 using a qualitative content analysis approach.
View Article and Find Full Text PDFRobust estimation of skin physiological parameters from hyperspectral images using Bayesian neural networks.
J Biomed Opt
January 2025
University of Ljubljana, Faculty of Mathematics and Physics, Ljubljana, Slovenia.
Significance: Machine learning models for the direct extraction of tissue parameters from hyperspectral images have been extensively researched recently, as they represent a faster alternative to the well-known iterative methods such as inverse Monte Carlo and inverse adding-doubling (IAD).
Aim: We aim to develop a Bayesian neural network model for robust prediction of physiological parameters from hyperspectral images.
Approach: We propose a two-component system for extracting physiological parameters from hyperspectral images.
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