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Evaluation of serum protein electrophoresis and immunofixation in dogs seropositive for various vector-borne pathogens.
Vet Clin Pathol
December 2024
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Background: Canine vector-borne diseases (VBDs) induce non-specific dysproteinemias, detectable by serum protein electrophoresis (SPE). VBDs have been reported to induce a monoclonal gammopathy pattern. Monoclonal gammopathies are commonly the result of paraprotein (M-protein) produced by an immunoglobulin-secreting neoplasm.
View Article and Find Full Text PDFTumor necrosis factor receptor 1-associated periodic syndrome without fever: cytokine profile before and during etanercept treatment.
Rheumatol Int
December 2009
Section of Pediatric Rheumatology and Osteology, Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
The objectives of this study are autoinflammatory syndromes which are usually characterized by repeated attacks of fever, especially in children. The presentation of these diseases, however, varies between entities and between patients of a particular syndrome. We report a 16-year-old female patient, who suffered from periodic erythema and myositis/fasciitis.
View Article and Find Full Text PDFSerum protein concentrations from clinically healthy horses determined by agarose gel electrophoresis.
Vet Clin Pathol
March 2009
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Background: Serum protein electrophoresis is a useful screening test in equine laboratory medicine. The method can provide valuable information about changes in the concentrations of albumin and alpha-, beta-, and gamma-globulins and thereby help characterize dysproteinemias in equine patients. Reference values for horses using agarose gel as a support medium have not been reported.
View Article and Find Full Text PDFCytoplasmic cytokines in lymphoproliferative disorders: multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia.
Leuk Lymphoma
August 2000
Department of Pathology, School of Medicine, Fukuoka University, Japan.
Cytokines play an important role in the pathogenesis of lymphomas via autocrine or paracrine mechanisms, or both. Here we determined the proportion of CD3-positive T lymphocytes containing various types of cytokines in enlarged lymph nodes. Lymph nodes were obtained from 16 patients with various lymphoproliferative disorders, including 3 cases with angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), 3 cases with adult T cell leukemia/lymphoma (ATLL), 2 cases with T-cell nonspecific malignant lymphoma (T-ML), 3 cases with B-cell diffuse large malignant lymphoma (BDL), 3 cases with histiocytic necrotizing lymphadenitis (HNL), and 2 cases with non-specific lymphadenitis (NSL).
View Article and Find Full Text PDFSuccessful treatment of immunoblastic lymphadenopathy-like T-cell lymphoma with cyclosporin A.
Leuk Lymphoma
October 1999
Department of Internal Medicine, Asahikawa Kosei General Hospital, Japan.
Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is considered to belong to peripheral T-cell lymphoma. Its prognosis is grave and effective treatments have not been established. Recently, we gave oral cyclosporin A (CsA) to a patient with IBL-like T-cell lymphoma, and succeeded in achieving dramatic remission.
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