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Targeted and untargeted cross-sectional study for sex-specific identification of plasma biomarkers of COVID-19 severity.
Anal Bioanal Chem
December 2024
Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Coronavirus disease 2019 is a highly contagious respiratory illness caused by the coronavirus SARS-CoV-2. Symptoms can range from mild to severe and typically appear 2-14 days after virus exposure. While vaccination has significantly reduced the incidence of severe complications, strategies for the identification of new biomarkers to assess disease severity remains a critical area of research.
View Article and Find Full Text PDFProcoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets.
J Vis Exp
November 2024
Department of Haematology, University Hospital of Bordeaux; Inserm U1034, Biology of Cardiovascular Disease.
Activated platelets promote coagulation primarily by exposing the procoagulant phospholipid phosphatidylserine (PS) on their outer membrane surfaces and releasing PS-expressing microvesicles that retain the original membrane architecture and cytoplasmic components of their originating cells. The accessibility of phosphatidylserine facilitates the binding of major coagulation factors, significantly amplifying the catalytic efficiency of coagulation enzymes, while microvesicle release acts as a pivotal mediator of intercellular signaling. Procoagulant platelets play a crucial role in clot stabilization during hemostasis, and their increased proportion in the bloodstream correlates with an increased risk of thrombosis.
View Article and Find Full Text PDFThe Chinese herbal prescription Kang-Gong-Yan alleviates cervicitis by modulating metabolites and gut microbiota.
Pharm Biol
December 2024
State Key Laboratory of Functions and Applications of Medicinal Plants and School of Pharmacy, Guizhou Medical University, Guiyang, China.
Context: Cervicitis is a common gynecological inflammatory disease. The Chinese herbal prescription Kang-Gong-Yan (KGY) is clinically effective against cervicitis; however, the chemical constituents and therapeutic mechanism of KGY remain elusive.
Objective: To analyze the chemical constituents of KGY and explore the potential mechanism of KGY in treating cervicitis.
Lupus anticoagulant associated with low grade B-cell lymphoma and IgM paraproteinaemia with lupus cofactor phenomenon on DRVVT and SCT assays - a possible novel association.
Thromb J
December 2024
Department of Pathology, Queen Elizabeth Hospital, Block M, 30 Gascoigne Road, Kowloon, Hong Kong.
Article Synopsis
- - The article discusses lupus anticoagulant (LA), which is a phenomenon causing abnormal results in blood clotting tests, specifically highlighting its association with lymphoma and IgM paraproteinaemia.
- - Two cases of low grade B-cell lymphoma were presented, both showing positive results for LA and a "lupus cofactor effect" in specific blood assays, indicating an unusual relationship between these conditions.
- - The findings suggest that diluting patient samples with normal pooled plasma is crucial for accurately evaluating LA status in cases of low grade B-cell lymphoma, as certain tests may yield false negatives without dilution.
Genome-Wide Identification and In Silico Analysis of Annexins in Chickpea (Cicer arietinum L.).
Biochem Genet
December 2024
Department of Botany, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, 495009, India.
Article Synopsis
- Annexins are a group of proteins involved in calcium-mediated signaling, playing a key role in how plants respond to various stresses.
- This study focused on chickpeas (Cicer arietinum L.), identifying 13 annexin sequences in their genome and analyzing their structure and expression, revealing the presence of multiple exons and differential gene expression across different tissues.
- The research suggests that these annexins may influence plant growth and development during normal and stressful conditions, providing insights for further studies on their functions.
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