AI Article Synopsis
- The study examined pleural effusion fluid from 11 patients with metastatic cancer to see if it could disperse MDCK cell colonies in vitro, with 4 samples showing positive results.
- Two of these positive samples underwent further purification which revealed that they eluted at similar positions as known sources of hepatocyte growth factor/scatter factor (HGF/SF).
- This research marks the first identification of significant amounts of HGF/SF in the pleural fluid of patients with malignant pleural spread.
Article Abstract
Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a cation exchange Mono S column. Active material from both lung samples, eluted at the same positions as factor from cultured human lung fibroblasts (MRC-5) and human placenta but in a slightly different position to murine scatter factor. In both cases the semi-purified active agent was identified as hepatocyte growth factor/scatter factor (HGF/SF) using an ELISA detection system specific for human HGF/SF. This is the first report identifying the presence of significant amounts of HGF/SF in the pleura of patients where malignant spread has occurred.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977819 | PMC |
| http://dx.doi.org/10.1038/bjc.1992.251 | DOI Listing |
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