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Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses.
Front Vet Sci
August 2023
Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States.
Background: Pain management is critical to equine welfare with non-steroidal anti-inflammatory drugs (NSAID) commonly used in horses. However, systemic NSAID use is limited by harmful gastrointestinal and renal side effects. Intravenous regional limb perfusion (IVRLP) is a technique used in horses that produces high, local antibiotic concentrations while limiting systemic circulation.
View Article and Find Full Text PDFInvestigation of phenylbutazone and its metabolite oxyphenbutazone in horse meat products during years 2013-2017.
Drug Test Anal
March 2018
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy.
This study showed the results of a monitoring program aimed at detecting the fraudulent use of horse meat in samples collected in the framework of official controls during the years 2013-2017 after the so-called horse meat scandal that caused a decreasing consumer confidence in the food industry, particularly in meat products. A total of 125 samples diversely distributed in the 5 years of monitoring were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method was validated according to Commission Decision 657/2002/EC with regard to the following parameters: linearity, specificity, decision limit (CCα), detection capability (CCβ), recovery, and precision (repeatability and within-laboratory reproducibility).
View Article and Find Full Text PDFEffects of single-dose intravenous phenylbutazone on experimentally induced, reversible lameness in the horse.
J Vet Pharmacol Ther
February 2008
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
The objective was to test the hypothesis that phenylbutazone (PBZ) alleviates lameness in an adjustable heart bar shoe model of equine foot pain. Eight Quarter Horse mares underwent 4-weekly treatments randomly: 0.9% saline placebo (SAL: 1 mL/45 kg body weight i.
View Article and Find Full Text PDFAntirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.
Res Commun Mol Pathol Pharmacol
July 2007
Local Health Unit of Parma, Bassa Est, N4, 43100 Parma, Italy.
The antirheumatic effect of pirfenidone was compared with a positive control drug, oxyphenbutazone which is used in patients suffering from rheumatoid arthritis, in a double blind clinical trial in humans. The data collected in this pilot project revealed that pirfenidone was more effective (p < 0.025) than oxyphenbutazone in providing relief from arthritic pain.
View Article and Find Full Text PDFToxic epidermal necrolysis (Lyell syndrome). Incidence and drug etiology in France, 1981-1985.
Arch Dermatol
January 1990
Service de Dermatologie, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
We looked retrospectively for all cases of toxic epidermal necrolysis that occurred in France over a 5-year period to appreciate the incidence of this disorder and its drug etiology. Of the 399 cases identified, we obtained detailed information on 344 cases and validated 253 cases. From response rates (66% to 98%), we estimated the actual total number of cases to be 333, and the incidence of toxic epidermal necrolysis in France to 1.
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