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In vivo study of nano chitosan beads-based ELISA versus traditional sandwich ELISA for the early diagnosis of trichinosis.
Exp Parasitol
January 2025
Medical Parasitology, Faculty of Medicine, Beni-Suef University, Egypt. Electronic address:
Human trichinosis is a serious foodborne parasitic zoonosis. Diagnosing human trichinosis is usually difficult due to the nonspecific clinical picture and the limited effectiveness of serological tests in acute infections. While ELISA can detect circulating Trichinella antigens, aiding in early diagnosis, its sensitivity may be low.
View Article and Find Full Text PDFTrichinella spiralis alleviates LPS-induced acute lung injury by modulating the protective Th2 immune response.
Vet Parasitol
January 2025
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. Electronic address:
Sepsis is a disorder of immune regulation caused by pathogenic microorganisms. A large number of inflammatory factors and inflammatory mediators are released, resulting in systemic inflammatory response disorder and acute lung injury (ALI). Helminths infection activate Th2 cytokines and immunomodulatory pathways, which have the function of anti-infection effector molecules.
View Article and Find Full Text PDFMoxidectin versus Ivermectin in the prevention and treatment of acute and chronic experimental trichinellosis.
Exp Parasitol
July 2024
Department of Medical Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address:
The limited activity of the traditional medications against T. spiralis encysted larvae handicaps complete cure of trichinellosis till now due to decreased permeability and absorption through tissues. MOX is listed worldwide for prevention and treatment of several internal and external nematodes.
View Article and Find Full Text PDFHelminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way.
mBio
June 2024
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Article Synopsis
- Hyperactivation of pro-inflammatory cytokines like TNF-α and IFN-γ is linked to the severe inflammation seen in COVID-19, resembling cytokine storms experienced during the disease.
- Infection with helminths (specifically Ts) has shown protective effects against such immune-induced shocks, with this protection being dependent on interleukin-9 (IL-9).
- The study highlights that treatment with recombinant IL-9 can improve survival in mice infected with SARS-CoV-2 and suggests that identifying anti-inflammatory substances from helminth excretory/secretory products could offer new strategies for reducing harmful inflammation during infections like COVID-19.
Common Intestinal Parasites.
Am Fam Physician
November 2023
Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Parasites are a source of significant illness worldwide. In the United States, giardiasis, cryptosporidiosis, cyclosporiasis, and trichinellosis are nationally notifiable conditions. Pinworm, the most common intestinal parasite in children, is not a locally notifiable infection.
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