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Primary Cardiac Myxofibrosarcoma of the Left Atrium with Heterologous Elements Mimicking a Cardiac Myxoma.
Am J Case Rep
January 2025
Department of Anatomic Pathology and Cytopathology, University Hospital "Dr. José Eleuterio González", Monterrey, Mexico.
BACKGROUND Primary cardiac malignancies are extremely rare, with an incidence of 0.07% on autopsy series. Primary sarcomas represent up to 95% of malignant neoplasms, with myxofibrosarcomas accounting for only 10%.
View Article and Find Full Text PDFThe Complex Role of Matrix Metalloproteinase-2 (MMP-2) in Health and Disease.
Int J Mol Sci
December 2024
Pittsburgh Heart, Lung and Blood Vascular Medicine Institute (VMI), University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Matrix metalloproteinase-2 (MMP-2), a zinc-dependent enzyme, plays a critical role in the degradation and remodeling of the extracellular matrix (ECM). As a member of the gelatinase subgroup of matrix metalloproteinases, MMP-2 is involved in a variety of physiological processes, including tissue repair, wound healing, angiogenesis, and embryogenesis. It is primarily responsible for the degradation of type IV and V collagen, fibronectin, laminin, and elastin, which are essential components of the ECM.
View Article and Find Full Text PDFTreatment of malignant primary cardiac tumors requires attention to cardiovascular complications: a single-center, retrospective study.
Jpn J Clin Oncol
October 2024
Department of Oncology and Social Medicine, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan.
Article Synopsis
- - The study analyzed records of 47 patients with primary cardiac tumors from Kyushu University Hospital, finding that 13 (28%) were diagnosed with malignant tumors, including various sarcomas and lymphomas, highlighting the rarity of such cases.
- - Cardiovascular complications were prevalent, with 77% of patients experiencing issues like heart dysfunction, arrhythmias, and right heart failure, often linked to the aggressive multimodal treatment involving surgery, chemotherapy, and radiotherapy.
- - Two cases exemplified severe complications: one patient faced significant heart failure post-treatment, while another developed a heart block due to tumor placement, indicating the need for careful management to improve patient outcomes.
Optimized new Shengmai powder inhibits myocardial fibrosis in heart failure by regulating the rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases signaling pathway.
J Tradit Chin Med
June 2024
Department of Cardiovascular, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
Objective: Exploring the effect of Optimized New Shengmai powder (, ONSMP) on myocardial fibrosis in heart failure (HF) based on rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase kinase (MEK)/extracellular regulated protein kinases (ERK) signaling pathway.
Methods: Randomized 70 Sprague-Dawley rats into sham ( 10) and operation ( 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. We randomly divided the operation group rats into the model, ONSMP [including low (L), medium (M), and high (H) dose], and enalapril groups.
A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review.
Cancer Rep (Hoboken)
April 2024
Department of Radiation Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Primary cardiac myxofibrosarcoma is a rare and aggressive malignancy, with the majority of approaching strategies relying on case reports. This article provides insights into its diagnosis and treatment.
Case Presentation: This paper presents the case of a 40-year-old man with sudden onset hemoptysis, leading to the diagnosis of primary cardiac myxofibrosarcoma.
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