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Klotho, Aging, and the Failing Kidney.
Front Endocrinol (Lausanne)
May 2021
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Article Synopsis
- Klotho is a gene linked to aging in mammals, regulating phosphate levels and the action of fibroblast growth factors, particularly FGF23.
- The decline in Klotho levels with age is associated with phosphate toxicity, making Klotho a key target for therapies aimed at age-related diseases, especially chronic kidney disease (CKD).
- Various strategies, including Klotho administration and modulation of diet and gut microbiota, have been explored to boost Klotho expression, showing promise for enhancing health and resilience in aging populations.
Nitric oxide-cytokinin interplay influences selenite sensitivity in Arabidopsis.
Plant Cell Rep
October 2016
Department of Plant Biology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, 6726, Szeged, Hungary.
Selenite oppositely modifies cytokinin and nitric oxide metabolism in Arabidopsis organs. A mutually negative interplay between the molecules exists in selenite-exposed roots; and their overproduction causes selenite insensitivity. Selenium-induced phytotoxicity is accompanied by developmental alterations such as primary root (PR) shortening.
View Article and Find Full Text PDFOntogenesis of the rumen: a comparative analysis of the Merino sheep and Iberian red deer.
Anim Sci J
February 2011
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Extremadura, Cáceres, Spain.
The aim of this study is to describe differences in the ontogenesis of the rumen in the sheep (domestic ruminant) and deer (wild ruminant). A total of 50 embryos and fetuses of Merino sheep and 50 of Iberian deer were used, from the first stages of prenatal life until birth. For the study, the animals were divided into five experimental groups according to the most relevant histological characteristics.
View Article and Find Full Text PDFAntibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora.
Regul Toxicol Pharmacol
November 2005
TechLab, Inc., 2001 Kraft Drive, Blacksburg, VA 24060-6358, USA.
A chemostat model of the healthy human large bowel ecosystem was used to establish no effect levels for tetracycline, neomycin, and erythromycin. For each compound, the equivalent to four oral doses (0, 1.5, 15, and 150 mg/60 kg person/d) was studied.
View Article and Find Full Text PDFDrug metabolizing enzyme system and heme pathway in hepatocarcinogenesis.
Cancer Biochem Biophys
July 1999
Centro de Investigaciones sobre Porfirinas y Porfirias, (CONICET-FCEN, UBA), Cuidad Universitaria, Pabellón II, Buenos Aires, Republica Argentina.
Chemically induced and spontaneous liver tumors share some metabolic alterations. The decline in hemoprotein levels during hepatocarcinogenesis may result from a diminution of the intracellular heme pool. To elucidate if the onset of the pre-initiation stage alters the natural regulation mechanism of heme pathway, animals were fed with p-dimethylaminoazobenzene (DAB) and treated or not with 2-allylisopropylacetamide (AIA).
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