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Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats.
J Negat Results Biomed
May 2016
Center for Narcolepsy, Sleep and Health Research, University of Illinois at Chicago, 845 South Damen Avenue (M/C 802), Chicago, IL, 60612, USA.
Background: Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex apnea and increases genioglossus activity, and reflex apnea attenuation is blocked by systemic pre-treatment with cannabinoid type 1 and/or type 2 receptor antagonists. However, it is unclear whether dronabinol has similar effects in the central nervous system; CB receptors are widely distributed in the brain, especially on neuronal circuitry important for respiration and upper airway activation.
View Article and Find Full Text PDFCannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats.
PLoS One
January 2016
Center for Narcolepsy, Sleep and Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America; Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, Illinois, United States of America; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper airway muscle activation/patency and disrupting respiratory rhythmogenesis. Vagal afferent neurons are inhibited by cannabinoid type 1 (CB1) or cannabinoid type 2 (CB2) receptors in animal models of vagally-mediated behaviors.
View Article and Find Full Text PDFIntranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat.
Respir Physiol Neurobiol
January 2014
Center for Narcolepsy, Sleep and Health Research, University of Illinois at Chicago, Chicago, IL, USA; Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, IL, USA. Electronic address:
Obstructive sleep apnea represents a significant public health concern. Afferent vagal activation is implicated in increased apnea susceptibility by reducing upper airway muscle tone via activation of serotonin receptors in the nodose ganglia. Previous investigations demonstrated that systemically administered cannabinoids can be used therapeutically to decrease the apnea/hypopnea index in rats and in humans.
View Article and Find Full Text PDFProof of concept trial of dronabinol in obstructive sleep apnea.
Front Psychiatry
January 2013
Department of Medicine, University of Illinois at Chicago Chicago, IL, USA.
Study Objective: Animal data suggest that Δ(9)-TetraHydroCannabinol (Δ(9)THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep apnea. On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)THC), an exogenous Cannabinoid type 1 and type 2 (CB1 and CB2) receptor agonist in patients with Obstructive Sleep Apnea (OSA).
Design And Setting: Proof of concept; single-center dose-escalation study of dronabinol.
5HT2 and 5HT3 receptors' contribution to modeling of post-serotonin respiratory pattern in cats.
Life Sci
September 2004
Laboratory of Respiration Physiology, PAS Medical Research Center, 5 Pawiñskiego St., 02-106 Warsaw, Poland.
Cardio-respiratory reflex effects of an exogenous serotonin challenge are suggested to be modulated by activation of the peripheral 5HT2 and 5HT3 receptors. In the present experiments the blocking effects of serotoninergic active drugs: ketanserin and tropanserin (MDL 72222) were studied in six pentobarbitone-chloralose anaesthetized cats. Bolus injection of serotonin (0.
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