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African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in which single or double amino acid substitutions were introduced to reduce or abrogate the binding to red blood cells and reduce virus persistence in blood. The mutant CD2v proteins were expressed at similar levels to the wildtype protein on the surface of infected cells.
View Article and Find Full Text PDFASF -survivors' Sera Do Not Inhibit African Swine Fever Virus Replication .
J Vet Res
March 2022
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Puławy, Poland.
Introduction: African swine fever virus (ASFV) causes one of the most dangerous diseases of pigs and wild boar - African swine fever (ASF). Since its second introduction into Europe (in 2007), the disease has been spreading consistently, and now ASF-free European countries are at risk. Complex interactions between the host's immune system and the virus have long prevented the development of a safe vaccine against ASF.
View Article and Find Full Text PDFIdentification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity.
Vet Res
December 2021
College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.
The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are viral entry proteins and are recognized as the major virulence determinants. Previously, a lentogenic NDV virus (CE16) was derived from a mesogenic strain (CI10) through sequential passages in chick embryos. Whole-genome sequence analysis revealed that the two homologous strains shared the same F protein but differed in HN with two amino acid (aa) substitutions (A215G and T430A).
View Article and Find Full Text PDFThe potential anti-African swine fever virus effects of medium chain fatty acids on feed model: An evaluation study using epidemic ASFV strain circulating in Vietnam.
Open Vet J
December 2021
Department of Biochemistry and Immunology, National Institute of Veterinary Research (NIVR), Hanoi, Vietnam.
Background: African swine fever (ASF) is an important disease affecting swine and has a significant economic loss in both the developed and developing world.
Aim: In this study, we evaluated the potential effects of medium-chain fatty acids (MCFAs) in individual and synergistic forms to prevent and/or reduce ASF virus (ASFV) infection using feed model.
Methods: The cytotoxicity of MCFAs on porcine alveolar macrophages cells was evaluated by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Stability of African swine fever virus on spiked spray-dried porcine plasma.
Transbound Emerg Dis
September 2021
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
African swine fever (ASF) is a viral disease that affects members of the Suidae family. The notifiable disease is considered a major threat to the pig industry, animal health, and food security worldwide. According to the European Food Safety Authority, ASF virus (ASFV) survival and transmission in feed and feed materials is a major research gap.
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