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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis.
Antioxidants (Basel)
January 2025
Department of Health Sciences, Università degli Studi di Milano, 20142 Milan, Italy.
The role of mitochondria as the electric engine of cells is well established. Over the past two decades, accumulating evidence has pointed out that, despite the presence of a highly active glycolytic pathway (Warburg effect), a functional and even upregulated mitochondrial respiration occurs in cancer cells to meet the need of high energy and the biosynthetic demand to sustain their anabolic growth. Mitochondria are also the primary source of intracellular ROS.
View Article and Find Full Text PDFKadozan Chitosan Formulation Enhances Postharvest Quality of Fresh Indian Jujube Fruit.
Foods
January 2025
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Indian jujube fruit is prone to perishing, resulting in a shorter shelf life after harvest. Kadozan is a liquid chitosan formulation that has a significant effect on fruit preservation. In order to explore its efficacy, the quality, and storability indicators of Indian jujube fruit were evaluated during storage at 15 ± 1 °C for 18 days.
View Article and Find Full Text PDFComparative metagenomics of tropical reef fishes show conserved core gut functions across hosts and diets with diet-related functional gene enrichments.
Appl Environ Microbiol
January 2025
School of Marine Science and Policy, University of Delaware, Lewes, Delaware, USA.
Unlabelled: Fish gut microbial communities are important for the breakdown and energy harvesting of the host diet. Microbes within the fish gut are selected by environmental and evolutionary factors. To understand how fish gut microbial communities are shaped by diet, three tropical fish species (hawkfish, ; yellow tang, ; and triggerfish, ) were fed piscivorous (fish meal pellets), herbivorous (seaweed), and invertivorous (shrimp) diets, respectively.
View Article and Find Full Text PDFHypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor.
Int J Mol Sci
January 2025
School of Applied Sciences, College of Health, Science and Society, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK.
The active metabolite of vitamin D3, calcitriol (1,25D), is widely recognised for its direct anti-proliferative and pro-differentiation effects. However, 1,25D is calcaemic, which restricts its clinical use for cancer treatment. Non-calcaemic agonists of the vitamin D receptor (VDR) could be better candidates for cancer treatment.
View Article and Find Full Text PDFPlatelet Mitochondrial Function and Endogenous Coenzyme Q Levels Could Be Used as Markers of Mitochondrial Health in Infertile Men: A Pilot Study.
Int J Mol Sci
December 2024
Faculty of Medicine, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Fertility disorders are a worldwide problem affecting 8-12% of the population, with the male factor substantially contributing to about 40-50% of all infertility cases. Mitochondria, crucial organelles for cellular viability, play a pivotal role in the processes of spermatogenesis and significantly affect sperm quality and their fertilizing ability. Mitochondrial oxidative phosphorylation (OXPHOS) dysfunction, reduced energy supply for sperm, reduced endogenous coenzyme Q (CoQ) levels, and oxidative stress are among the main factors that contribute to male infertility.
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