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The Carnivoran Adaptive Landscape Reveals Trade-offs among Functional Traits in the Skull, Appendicular, and Axial Skeleton.
Integr Org Biol
January 2025
Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Analyses of form-function relationships are widely used to understand links between morphology, ecology, and adaptation across macroevolutionary scales. However, few have investigated functional trade-offs and covariance within and between the skull, limbs, and vertebral column simultaneously. In this study, we investigated the adaptive landscape of skeletal form and function in carnivorans to test how functional trade-offs among these skeletal regions contribute to ecological adaptations and the topology of the landscape.
View Article and Find Full Text PDFThe role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy.
Front Immunol
January 2025
Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.
Colorectal cancer (CRC) is one of the most prevalent and deadly malignancies worldwide. Recently, ferroptosis, a novel form of regulated cell death characterized by iron dependency and lipid peroxidation, has garnered significant attention from researchers. The mechanisms underlying ferroptosis, including intracellular iron levels, lipid peroxidation, and antioxidant system regulation, offer new insights into cancer treatment strategies.
View Article and Find Full Text PDFSquamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus.
Front Immunol
January 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States.
Squamate reptiles are amongst the most successful terrestrial vertebrate lineages, with over 10,000 species across a broad range of ecosystems. Despite their success, squamates are also amongst the least studied lineages immunologically. Recently, a universal lack of γδ T cells in squamates due to deletions of the genes encoding the T cell receptor (TCR) γ and δ chains was discovered.
View Article and Find Full Text PDFFunctional Improvements by Controlled Suture Tension in Arthroscopic Rotator Cuff Repair.
JB JS Open Access
January 2025
Department of Orthopaedic Surgery, University Hospital, Shiga University of Medical Science, Shiga, Japan.
Background: Although a certain degree of tension in bridging sutures is required for proper tendon healing following suture-bridge rotator cuff repair, excessive suture tension may be detrimental to tendon healing. This study aimed to investigate the effects of bridging suture tension on clinical outcomes and tendon healing. We hypothesized that fixed, low tension of the bridging sutures would improve the tendon healing rate and clinical outcomes compared with maximum manual tensioning.
View Article and Find Full Text PDFSurgical interventions for degenerative cervical disease: Impact on patient quality of life, mental health, pain relief, and spiritual health.
Heliyon
January 2025
Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 83301.
Introduction: Degenerative cervical diseases can severely affect patients' quality of life (QOL), mental health, and physical function. While surgical intervention is a common treatment, its impact on holistic well-being, including spiritual health, has not been thoroughly explored. This study aimed to evaluate the effects of surgery on QOL, pain-related disability, mental health, and spiritual well-being in patients with degenerative cervical diseases.
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