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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape.
Front Immunol
January 2025
State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Center for Cell Lineage Research, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Background: Although immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.
Methods: We retrieved the germline sequences for the IGHV from the IMGT database to illustrate the amino acid polymorphism present within germline sequences of IGHV genes. We aassembled the sequences of IgM and IgD repertoire from 130 people to investigate the genetic variations in the population.
Optimizing antibody stability and efficacy in CD47- SIRPα inhibition via computational approaches.
Mol Divers
January 2025
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Mohali, Punjab, 160062, India.
CD47, a cell surface protein, serves as a "don't eat me" signal that prevents immune cells from engulfing healthy cells upon its interaction with SIRPα. Cancer cells exploit this mechanism by overexpressing CD47 to evade immune destruction. Blocking the interaction between CD47 and its receptor, SIRPα, is a promising therapeutic strategy.
View Article and Find Full Text PDFAntiBinder: utilizing bidirectional attention and hybrid encoding for precise antibody-antigen interaction prediction.
Brief Bioinform
November 2024
Research Center for Social Intelligence, Fudan University, Handan Street, Shanghai 200433, China.
Antibodies play a key role in medical diagnostics and therapeutics. Accurately predicting antibody-antigen binding is essential for developing effective treatments. Traditional protein-protein interaction prediction methods often fall short because they do not account for the unique structural and dynamic properties of antibodies and antigens.
View Article and Find Full Text PDFUltrasensitive colorimetric detection of deoxynivalenol in infant milk powder based on the inhibitory effect of silver ions on the peroxidase-like activity of Ni@Pt nanoparticles.
Food Chem
January 2025
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:
Deoxynivalenol, a hazardous mycotoxin, poses significant health risks to humans and animals, necessitating highly sensitive detection methods due to its low abundance in food. Herein, we present a colorimetric sensing strategy for deoxynivalenol detection based on the inhibitory effect of silver ions on the peroxidase-like activity of Ni@Pt nanoparticles. Silver ions adsorb onto the surface of Ni@Pt nanoparticles, blocking the active site and consequently impeding their catalytic activity.
View Article and Find Full Text PDFAmino Acids Frequency and Interaction Trends: Comprehensive Analysis of Experimentally Validated Viral Antigen-Antibody Complexes.
Mol Biotechnol
January 2025
Innoplexus Consulting Services Pvt Ltd, Floor 7Th, Midas Tower, Rajiv Gandhi Infotech Park, Hinjawadi, Pune, Maharashtra, 411057, India.
Antibodies have specific binding capabilities and therapeutic potential for treating various diseases, including viral infections. The amino acid composition of the hypervariable complementarity determining regions (CDR) loops and the framework regions (FR) are the determining factors for the affinity and therapeutic efficacy of the antibodies. In this study selected and curated, 77 viral antigen-human antibody complexes from Protein data bank from the Thera-SAbdab database were analyzed.
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