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Simplified Method for the In Situ Collection and Laboratory Analysis of Cosmogenic Tracers (Sulfur-35 and Sodium-22) to Determine Residence Time Distributions and Water Ages.
Anal Chem
March 2021
Nuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
The use of cosmogenically produced sulfur-35 ( = 87 days) and sodium-22 ( = 2.6 years) as intrinsic tracers can provide valuable information on catchment hydrology, flow paths, and subsurface storage. A new and straightforward method was created to determine the activities of both S and Na in various water sources by pumping large volumes (up to 1000 L) of water through cation- and anion-exchange resin columns in the field to collect sodium and sulfate ions and simple chemistry in the lab.
View Article and Find Full Text PDFTreatment practices in the management of scabies in infants younger than two months.
Pediatr Dermatol
March 2021
Department of Dermatology, University of California, San Francisco, CA, USA.
Background/objectives: Efficacy and safety data of scabies treatments in infants are limited. Although topical permethrin is used in the treatment of scabies in adults, it is not approved for use in infants younger than 2 months of age in many parts of the world. This study aimed to describe treatment practices in the management of scabies in infants younger than 2 months.
View Article and Find Full Text PDFSynthesis of H, C , H C-SCH 430765 and S-SCH 500946, potent and selective inhibitors of the NPY receptor.
J Labelled Comp Radiopharm
June 2018
Department of Process Research and Development, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, USA.
SCH 430765 and SCH 500496 are potent and selective antagonists of the NPY receptor. NPY receptor antagonists have the potential for the treatment of obesity. [ S]SCH 500946 was prepared for a competition binding assay which led to the identification of SCH 430765.
View Article and Find Full Text PDFThe distribution, clearance, and safety of an anti-MMP-9 DNAzyme in normal and MMTV-PyMT transgenic mice.
Nucleic Acid Ther
December 2013
1 Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis Tennessee.
Catalytic oligonucleotides, known as DNAzymes, are a new class of nucleic acid-based gene therapy that have recently been used in preclinical animal studies to treat various cancers. In this study the systemic distribution, pharmacokinetics, and safety of intravenously administered anti-MMP (matrix metalloproteinase)-9 DNAzyme (AM9D) were determined in healthy FVB and in MMTV-polyoma virus middle T (PyMT) transgenic mice bearing mammary tumors. MMP-9 is known to be involved in tumor cell development, angiogenesis, invasion, and metastasis.
View Article and Find Full Text PDFN-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder.
Bipolar Disord
February 2010
Program for Cellular Neuropathology, McLean Hospital, Belmont, MA 02478, USA.
Objectives: Inhibitory neural circuits and the glutamatergic regulation of these circuits in the cerebral cortex appear to be disturbed in bipolar disorder. In this study, we addressed the hypothesis that, in the prefrontal cortex (PFC), disturbances of glutamatergic regulation of the class of inhibitory neurons that contain the calcium buffer parvalbumin (PV) via N-methyl-D-aspartate (NMDA) receptor may contribute to the pathophysiology of bipolar disorder.
Methods: We used double in situ hybridization with a sulfur-35-labeled riboprobe for the NR2A subunit of the NMDA receptor and a digoxigenin-labeled riboprobe for PV in a cohort of 18 subjects with bipolar disorder and 18 demographically matched normal control subjects.
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