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Azoles display promising anticonvulsant effects through possible PPAR-α activation.
Neurosci Lett
April 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Baskent University, Ankara, Turkey.
Azoles such as nafimidone, denzimol and loreclezole are known for their clinical efficacy against epilepsy, and loreclezole acts by potentiating γ-aminobutyric acid (GABA)-ergic currents. In the current study, we report a series of azole derivatives in alcohol ester and oxime ester structure showing promising anticonvulsant effects in 6 Hz and maximal electro shock (MES) models with minimal toxicity. The most promising of the series, 5f, was active in both 6 Hz and MES tests with a median effective dose (ED) of 118.
View Article and Find Full Text PDFDifferential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice.
Curr Drug Metab
December 2023
Institute of Pharmaceutical Technology, Sree Padmavati MahilaVisvavidyalayam- Womens University, Tirupati, Andhra Pradesh, 517502, India.
Background: The beneficial effects of statins, other than their hypocholesterolemia role, have been well documented, however, their use as an adjuvant drug with other antiseizure drugs, in the treatment of epilepsy is poorly understood.
Objective: This study aimed to investigate the symbiotic effect of ATOR along with either lacosamide (LACO) or levetiracetam (LEVE) on experimentally induced epilepsy (Maximal electro-shock-MES or pentylenetetrazol- PTZ) in mice models.
Methods: Conventional elevated-maze (EPM) and rotarod methods were performed to observe the behavioral effects.
Anticonvulsant effect of Sphaeranthus flower extracts in mice.
J Ayurveda Integr Med
January 2019
SPPSPTM, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400056, Maharashtra, India. Electronic address:
Sphaeranthus indicus whole herb is included as a Rasayana drug in Ayurveda and is reported for the treatment of epilepsy. S. indicus flowers have anxiolytic, hypotensive, peripheral vasodilatory and cathartic activity.
View Article and Find Full Text PDFEvaluation of Anti-Epileptic Effect of New Indole Derivatives by Estimation of Biogenic Amines Concentrations in Rat Brain.
Adv Exp Med Biol
May 2019
Medicinal Chemistry Laboratory, U.C.P.Sc., Kakatiya University, Wararagal, 506009, Telangana, India.
The new heterocyclic compounds are used to treat epilepsy. In the present work new indole derivatives i.e.
View Article and Find Full Text PDFIncrease in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides.
Epilepsy Res
September 2017
Department of Pharmacology, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India. Electronic address:
Background And Objective: Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Sepsis is a condition which initiates a cascade of a surge of inflammatory mediators. Interplay between seizures and inflammation other than of brain origin is yet to be explored.
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