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Tumor microenvironment-responsive and modulatory manganese-based nanoenzyme for enhanced tumor immunotherapy.
Front Pharmacol
January 2025
Department of General Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
The characteristics of the tumor microenvironment (TME) have a close and internal correlation with the effect of cancer immunotherapy, significantly affecting the progression and metastasis of cancer. The rational design of nanoenzymes that possess the ability to respond to and regulate the TME is driving a new direction in catalytic immunotherapy. In this study, we designed a multifunctional manganese (Mn)-based nanoenzyme that is responsive to acidic pH and overxpressed HO at tumor site and holds capability of modulating hypoxic and immunosuppressive TME for synergistic anti-tumor photothermal/photodynamic/immunotherapy.
View Article and Find Full Text PDFPrimary Dentin Conditioning with Methylene Blue Activated Photodynamic Therapy, Phytic Acid, and Er,Cr:YSGG to Resin-Modified Glass Ionomer Cement in Comparison to Conventional Polyacrylic Acid.
Photobiomodul Photomed Laser Surg
January 2025
Department of Preventive Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia.
Impact of surface conditioner phytic acid (IP6) Er,Cr:YSGG laser (ECYL) methylene blue photodynamic therapy (MB-PDT) on the microleakage and shear bond strength (SBS) of resin-modified glass ionomer cement (RMGIC) to primary sound dentin. Overall, 80 extracted sound primary molars were collected followed by their submergence in self-cure acrylic resin. The dentin surface was exposed and made flat and was assigned into four groups based on the surface conditioning.
View Article and Find Full Text PDFThe Role of Open-Shell Organic Radical in Enhancing Anti-Tumor Photocatalysis Reaction of NIR Light-Activated Photosensitizer.
Angew Chem Int Ed Engl
January 2025
Southern University of Science and Technology, Materials Science and Engineering, 1088 Xueyuan Blvd., Nanshan District, 518055, Shenzhen, CHINA.
Open-shell radical materials, which are characterized by unpaired electrons, have led to revolutionary breakthroughs in material science due to their unique optoelectronic properties. However, the involvement of organic radicals in photodynamic therapy (PDT) has rarely been reported or discussed. This work studies two photosensitizer analogs.
View Article and Find Full Text PDFCreating Single Atomic Coordination for Hypoxia-Resistant Pyroptosis Nano-Inducer to Boost Anti-Tumor Immunotherapy.
Adv Mater
January 2025
School of Pharmacy, Key Laboratory of Smart Drug Delivery (Ministry of Education), Fudan University, Shanghai, 201203, China.
General synthesis and mechanical understanding of type I nano-photosensitizers are of great importance for hypoxia-resistant pyroptosis inducers. Herein, a simple solvothermal treatment is developed to convert non-photosensitive small molecules (hemin) into uniform carbon nanodots (HNCDs) with strong type I photodynamic activity and red fluorescence emission. These HNCDs inherit the single atomic Fe-N center of hemin while creating sp-hybridized carbon surroundings, which synergistically modulated the energy level and electron transfer for converting the type II photodynamic process to type I.
View Article and Find Full Text PDFAcceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type-I and AIE-Active Photosensitizers for Targeting Ferroptosis-Based Cancer Therapy.
Adv Healthc Mater
January 2025
Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, China.
Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation-induced emission (AIE) activity offer a promising solution to achieve non-invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type-I ROS generation are still scarce and the structure-property relationship is still unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed to endow the AIEgen strong type-I ROS producibility.
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