Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC293323 | PMC |
| http://dx.doi.org/10.1172/JCI104057 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-term renoprotective effect of luseogliflozin in type 2 diabetes patients: CHikushi Anti-diabetes mellitus Trial-Lusefi (CHAT-Lu).
Drug Discov Ther
December 2024
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Several sodium-glucose cotransporter 2 (SGLT2) inhibitors are known to have beneficial effects on renal function in patients with type 2 diabetes. However, the long-term effects of luseogliflozin, an SGLT2 inhibitor, remain uncertain in real-world settings. This multicenter, open-label, prospective observational study evaluated the long-term effects of luseogliflozin on renal function in Japanese patients with type 2 diabetes.
View Article and Find Full Text PDFA non-purine inhibitor of xanthine oxidoreductase mitigates adenosine triphosphate degradation under hypoxic conditions in mouse brain.
Brain Res
January 2025
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, Japan. Electronic address:
The brain is an organ that consumes a substantial amount of oxygen, and a reduction in oxygen concentration can rapidly lead to significant and irreversible brain injury. The progression of brain injury during hypoxia involves the depletion of intracellular adenosine triphosphate (ATP) due to decreased oxidative phosphorylation in the inner mitochondrial membrane. Allopurinol is a purine analog inhibitor of xanthine oxidoreductase that protects against hypoxic/ischemic brain injury; however, its underlying mechanism of action remains unclear.
View Article and Find Full Text PDFDiscovery of cyanidin-3-O-galactoside as a novel CNT2 inhibitor for the treatment of hyperuricemia.
Bioorg Chem
December 2024
Good Clinical Practice Development, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. Electronic address:
Inhibition of human concentrative nucleoside transporter 2 (CNT2) could suppress increases in serum urate levels derived from dietary purines. However, the structural basis for substrate recognition of CNT2 is still unknown and only a few inhibitors have been reported. In this study, a homology model of CNT2 was constructed and residues T315, E316, N426, N491, E492, F536 and N538 were identified as binding sites for adenosine through site-directed mutagenesis and a H-adenosine uptake assay.
View Article and Find Full Text PDFEffects and mechanisms of theabrownin from black tea in improving hyperuricemia: Evidence from animal study and clinical trial.
Int J Biol Macromol
December 2024
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen 361102, China.
Article Synopsis
- Hyperuricemia (HUA) is a condition where excess uric acid builds up in the body, and Theabrownin (TB), a compound from black tea, may help improve this condition.
- TB was found to lower uric acid levels and reduce kidney damage in HUA mice by inhibiting an enzyme (xanthine oxidase) and enhancing uric acid transport in the kidneys.
- A clinical trial with HUA patients indicated that consuming TB daily for 12 weeks effectively decreased uric acid levels without negative side effects.
ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation in rats.
Turk J Med Sci
December 2024
Department of Pharmacology, the Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Medical University, Shijiazhuang, China.
Background/aim: Doxorubicin (Dox) is a potent anticancer medication. However, due to nephrotoxicity, its clinical application is restricted. (AM) is a plant used in traditional medicine to treat several conditions, including kidney disorders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!