[Reticuloses of the skin].

Dermatol Wochenschr

Published: November 1959

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In a series of papers from 1938 to 1949, Albert Sézary, a French dermatologist and syphilologist, described erythroderma with cellules monstrueuses (monster cells) in the skin and blood, which is now known as Sézary syndrome or Sézary disease. This historical note reprises the life and work of Sézary. It outlines his original reports and his thoughts about the pathogenesis of the disease as a reticulosis, and lists a composite classification of the reticuloses, which includes that of Sézary.

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Primary cutaneous B-cell lymphomas: then and now.

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Department of Dermatology, Medical University of Graz, Graz, Austria.

In the past, concepts of cutaneous lymphomas were based on careful clinical and classical histopathological descriptions. Most primary cutaneous B-cell lymphomas (pCBCL) were designated as lymphosarcoma, follicular lymphoma, histiocytic lymphoma, reticulum-cell sarcoma or skin reticuloses. Today, pCBCL are classified as a fully recognized and well-defined group of extranodal lymphomas according to the criteria of the World Health Organization-European Organization for Research and Treatment of Cancer classification.

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One hundred and fourteen BALB/cA and 89 hairless (hr/hr, Oslo strain) mice of both sexes were treated topically once a week on the dorsal skin for about 17 months with 18 nmol 12-0-tetradecanoylphorbol-13-acetate (TPA) in 0.2 ml acetone or with 0.2 ml acetone alone, and observed for up to 24 months.

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The new interpretation of the classical clinical, histological and cytomorphological findings by means of modern methods has led to older ideas of cutaneous lymphoreticular neoplasias having to give way to newer concepts. Most of the earlier reticuloses are today to be considered as cutaneous B cell lymphomata. The rest are divided among cutaneous T cell lymphomata, leukemias and malignant histiocytic diseases.

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