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Fission yeast GPI inositol deacylase Bst1 regulates ER-Golgi transport and functions in late stages of cytokinesis.
Mol Biol Cell
January 2025
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
The Munc13/UNC-13 family protein Ync13 is essential for septum integrity and cytokinesis in fission yeast. To further explore the mechanism of Ync13 functions, spontaneous suppressors of mutants, which can suppress the colony-formation defects and lysis phenotype of mutant cells, are isolated and characterized. One of the suppressor mutants, -, shows defects in the cytokinetic contractile ring constriction, septation, and daughter-cell separation, similar to mutant.
View Article and Find Full Text PDFSYS-1/beta-catenin inheritance and regulation by Wnt-signaling during asymmetric cell division.
Mol Biol Cell
January 2025
Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA.
Asymmetric cell division (ACD) allows daughter cells of a polarized mother to acquire different developmental fates. In , the Wnt/β-catenin Asymmetry (WβA) pathway regulates many embryonic and larval ACDs; here, a Wnt gradient induces an asymmetric distribution of Wnt signaling components within the dividing mother cell. One terminal nuclear effector of the WβA pathway is the transcriptional activator SYS-1/β-catenin.
View Article and Find Full Text PDFAge- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse.
Invest Ophthalmol Vis Sci
January 2025
State Key Laboratory of Ophthalmology, Optometry, and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Purpose: Changes associated with Alzheimer's disease (AD) may have measurable effects on the retina, which may facilitate early detection due to the eye's accessibility. Retinal pathology and the regulation of serine racemase (SR) were investigated in the retinas of APP(SW)/PS1(∆E9) mice.
Methods: SR in the retinas and the content of D-serine in the aqueous humor were analyzed.
Evaluating a Public Health Assessment and Response Framework: SARS-CoV-2 Spread Under the Controlled Distancing Model of Rio Grande do Sul, Brazil.
Health Secur
January 2025
Ricardo Rohweder, MSc, is a PhD Student, Programa de Pós-Graduação em Genética e Biologia Molecular; Lavinia Schuler-Faccini, PhD, is a Professor, Department of Genética and Programa de Pós-Graduação em Genética e Biologia Molecular; and Gonçalo Ferraz, PhD, is a Professor, Programa de Pós-Graduação em Ecologia and Programa de Pós-Graduação em Genética e Biologia Molecular; all at the Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Lavinia Schuler-Faccini is also a Professor, Medical Genetics Service of Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
In early 2020, to halt the spread of SARS-CoV-2, the state government of Rio Grande do Sul in Brazil established a public health assessment and response framework known as a "controlled distancing model." Using this framework, the government divided the state into 21 regions and evaluated them against a composite index of disease transmission and health service capacity. Regions were assessed using a color-coded scale of flags that was updated on a weekly basis and used to guide the adoption of nonpharmaceutical interventions.
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