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Early exposure to a cholinergic receptor blocking agent mitigates adult obesity and protects pancreatic islet function in male rats.
Am J Physiol Endocrinol Metab
January 2025
Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringa, Maringa, Brazil.
We tested the hypothesis that attenuation of the circulating insulin level in rats during early life can provide sustained protection against diet-induced obesity and metabolic dysfunction in adulthood. Male Wistar rats received intraperitoneal scopolamine butylbromide (SB) during the first 12 days of suckling, whereas control rats received 0.9% saline injections.
View Article and Find Full Text PDFOccult Nesidioblastosis Detected by 111In-Pentetreotide Single-Photon Emission Computed Tomography.
Acta Med Okayama
October 2024
Department of Gastroenteorlogical Surgery, Kochi Health Sciences Center.
Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia, is usually observed in children and infants, although more recently adult-onset nesidioblastosis has also been described. We present a case of nesidioblastosis in a 78-year-old man that was detected by 111In-pentetreotide single photon emission computed tomography (SPECT/CT). The patient was transferred to our hospital's emergency department in a hypoglycemic coma.
View Article and Find Full Text PDFConstitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice.
Int J Mol Sci
October 2024
Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660 Madrid, Spain.
Pleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, and glucose tolerance. Pleiotrophin deletion is associated with a lipodystrophic phenotype in which adipose tissue plasticity is altered in late life. This study explored the impact of pleiotrophin deletion on pancreatic morphology and function in later life.
View Article and Find Full Text PDFNesidioblastosis in Pregnancy: Navigating the Diagnostic and Therapeutic Challenges of a Rare Condition.
Cureus
October 2024
General Surgery, Rambam Medical Center, Haifa, ISR.
Article Synopsis
- * Managing nesidioblastosis includes both medical and surgical options, but effective treatments are not well understood, and the situation is even more complicated for pregnant patients due to limited information available.
- * A case study of a 22-year-old pregnant woman experiencing severe hypoglycemia highlights the challenges in diagnosing and treating this condition, emphasizing the need for more research to improve clinical practices.
Article Synopsis
- The study suggests that insulin resistance in the liver is a key factor leading to dysfunction in pancreatic islets, which is linked to Type 2 Diabetes Mellitus (T2DM) and Metabolic Associated Steatotic Liver Disease (MASLD).
- Researchers developed a microphysiological system combining liver and pancreatic models to better understand how these organ dysfunctions relate to each other. This system allows for the investigation of changes that occur when metabolic syndrome is present.
- Results showed that under metabolic syndrome conditions, the liver-pancreas system exhibited altered insulin secretion and signaling, indicating a direct connection between liver issues and islet dysfunction, which could help in developing personalized treatment strategies for affected patients.
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