Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Preclinical evaluation of the efficacy and safety of AAV8-TNAP-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia.
J Bone Miner Res
January 2025
Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP), with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4x108 up to 4x1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4x106 up to 4x109 (vg/b) was administered to 8-week-old AlplPrx1/Prx1 mice (a late-onset HPP model).
View Article and Find Full Text PDFSerosurvey of Visceral Leishmaniasis in Organ Transplant Recipients in the South of Iran.
Transplant Proc
January 2025
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Background: Visceral leishmaniasis (VL) can become active and cause specific problems in transplant recipients. The current study was conducted with the aim of serological evaluation of VL in transplant patients in a comprehensive transplantation center in Fars province southern Iran.
Methods: The study population included 150 organ transplant recipients.
Iron Chelation Prevents Age-Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging.
J Cachexia Sarcopenia Muscle
February 2025
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.
Background: A decline in skeletal muscle mass and function known as skeletal muscle sarcopenia is an inevitable consequence of aging. Sarcopenia is a major cause of decreased muscle strength, physical frailty and increased muscle fatigability, contributing significantly to an increased risk of physical disability and functional dependence among the elderly. There remains a significant need for a novel therapy that can improve sarcopenia and related problems in aging.
View Article and Find Full Text PDFObjective: This study aimed to assess the psychological health status of children aged 3-7 years in Wuxi and analyze the correlation between dietary behaviors, lifestyle, and psychological problems.
Methods: Using a stratified cluster random sampling method, 3-7-year-old children from 18 kindergartens across Wuxi were selected as the survey subjects. An online survey was conducted to collect demographic information about children and their parents, dietary information, lifestyle data, and family backgrounds.
Uncertainty modeling for inductive knowledge graph embedding.
Neural Netw
January 2025
College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518060, China; Guangdong Key Laboratory of Intelligent Information Processing, Shenzhen University, Shenzhen, 518060, China. Electronic address:
Article Synopsis
- In refining Knowledge Graphs, new entities appear and old ones change, leading to a problem of distribution shift for entity features during representation learning.
- Most current methods for embedding these graphs mainly focus on new entities and overlook the issues caused by this distribution shift.
- The proposed model, EDSU, uses mean and variance reconstruction to address this shift by integrating both the characteristics of entity embeddings and their neighborhood structures, resulting in improved performance in inductive link prediction tasks compared to existing models.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!