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Parvovirus B19 infection in children: a comprehensive review of clinical manifestations and management.
Ital J Pediatr
December 2024
Department of Pediatrics, Santa Maria delle Croci Hospital, AUSL della Romagna, Viale Vincenzo Randi, 5, Ravenna, Ravenna, 48121, RA, Italy.
Parvovirus B19 (B19V) is a significant pathogen responsible for a wide range of clinical manifestations, particularly in children and pregnant women. While B19V is most commonly recognized as the cause of Fifth disease, a mild erythematous illness in children, its clinical impact extends far beyond this condition. B19V can lead to severe complications, including transient aplastic crisis in individuals with chronic hemolytic anemias, arthralgia, and more severe joint diseases.
View Article and Find Full Text PDFAplastic Anemia With Non-Occlusive Mesenteric Ischemia.
Cureus
October 2024
Endocrinology and Diabetes, Hinchingbrooke Hospital, Huntingdon, GBR.
This case highlights the multifaceted challenges of managing aplastic anemia, especially when complicated by non-occlusive mesenteric ischemia (NOMI). The patient's clinical course underscores the importance of a conservative, multidisciplinary approach in balancing the risks of invasive procedures with the need for effective diagnostics and treatment. Recognizing the risks associated with pancytopenia, including life-threatening bleeding and infections, is critical in managing such patients.
View Article and Find Full Text PDFTransfusion-related acute lung injury/transfusion-associated circulatory overload in a child with non-transfusion dependent thalassemia and aplastic crisis due to acute parvovirus B19 infection.
BMJ Case Rep
October 2024
Blood Transfusion Center, University General Hospital of Alexandroupolis, Alexandroupolis, Thrace, Greece.
We present a never-transfused girl with thalassemia intermedia who was admitted for febrile aplastic crisis due to human parvovirus B19. After a first transfusion of packed red blood cells, she developed pulmonary oedema. She improved with supportive care including the use of intravenous diuretics.
View Article and Find Full Text PDFThe Aplastic Crisis in HbSS: Observations from the Jamaican Birth Cohort.
Hemoglobin
July 2024
Sickle Cell Trust (Jamaica), University of the West Indies, Kingston, Jamaica.
Article Synopsis
- A cohort study was conducted in Jamaica from 1973 to 1981, tracking 311 newborns with homozygous sickle cell disease (HbSS) to understand the prevalence and impact of aplastic crises.
- Out of the patients studied, 38% experienced clinically defined aplastic crises, typically around age 7.5, with most cases linked to parvovirus B19, although some did not show hematological changes.
- The study found that while symptoms were often nonspecific, correct diagnosis and management of these crises were generally effective, with a low recurrence rate and a few fatalities due to misdiagnosis or remote living conditions.
Clinical Presentations of Parvovirus B19: A Case Series.
Pediatr Infect Dis J
January 2025
From the Pediatric Infectious Disease Unit, Department of Paediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy.
Article Synopsis
- Parvovirus B19 (PVB19) is a small virus that often causes mild or no symptoms, but in children, it can lead to various conditions like rashes and joint pain.
- Three pediatric cases from Milan in March 2024 showed different manifestations of PVB19, including rashes and low platelet counts.
- The findings stress the virus’s potential complications, highlight the need for careful diagnosis during outbreaks, and point out the importance of understanding PVB19's epidemiological patterns for better management in children.
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