Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00000441-195912000-00008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lycopene supplementation reduces inflammatory, histopathological and DNA damage in an acute lung injury rabbit model.
Crit Care Sci
January 2025
Department of Physical Therapy, Universidade Federal de Uberlândia - Uberlândia (MG), Brazil.
Objective: To investigate the effects of lycopene supplementation on inflammation, lung histopathology and systemic DNA damage in an experimentally induced lung injury model, ventilated by conventional mechanical ventilation and high-frequency oscillatory ventilation, compared with a control group.
Methods: Fifty-five rabbits sampled by convenience were supplemented with 10mg/kg lycopene for 21 days prior to the experiment. Lung injury was induced by tracheal infusion of warm saline.
A transplantation study in the high-altitude ecosystem of Ladakh suggests site-specific microenvironment is key for physiological adaptation than altitude.
Plant Physiol Biochem
January 2025
Plant Sciences and Agrotechnology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu, J & K, 180001, India; Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India. Electronic address:
Transplantation experiments conducted in high altitude ecosystems are rising as key strategy to examine the response of individual plant transplanted across distinct elevations. However, plant physiological and biochemical performance in response to changes in abiotic factors across different species and mountain ranges is still lacking. So in the present study, we have made an attempt to link the physiological performance with that of altitudinal gradient in Ladakh by transplanting Lepidium latifolium at four different altitudinal sites.
View Article and Find Full Text PDFDehydration rapidly induces expression of NCED genes from a single subclade in diverse eudicots.
Planta
January 2025
School of Natural Sciences, University of Tasmania, Private Bag 55, Hobart, TAS, 7001, Australia.
A gene within a single subclade of NCED genes is triggered in response to both, short- and long-term dehydration treatments, in three model dicot species. During dehydration, some plants can rapidly synthesise the stress hormone abscisic acid (ABA) in leaves within 20 min, triggering the closure of stomata and limiting further water loss. This response is associated with significant transcriptional upregulation of Nine-cis-Epoxycarotenoid Dioxygenase (NCED) genes, which encode the enzyme considered to be rate-limiting in ABA biosynthesis.
View Article and Find Full Text PDFRetinoids and retinoid-binding proteins: Unexpected roles in metabolic disease.
Curr Top Dev Biol
January 2025
Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH, United States.
Alterations in tissue expression levels of both retinol-binding protein 2 (RBP2) and retinol-binding protein 4 (RBP4) have been associated with metabolic disease, specifically with obesity, glucose intolerance and hepatic steatosis. Our laboratories have shown that this involves novel pathways not previously considered as possible linkages between impaired retinoid metabolism and metabolic disease development. We have established both biochemically and structurally that RBP2 binds with very high affinity to very long-chain unsaturated 2-monoacylglycerols like the canonical endocannabinoid 2-arachidonoyl glycerol (2-AG) and other endocannabinoid-like substances.
View Article and Find Full Text PDFRetinoic acid homeostasis and disease.
Curr Top Dev Biol
January 2025
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States. Electronic address:
Retinoids, particularly all-trans-retinoic acid (ATRA), play crucial roles in various physiological processes, including development, immune response, and reproduction, by regulating gene transcription through nuclear receptors. This review explores the biosynthetic pathways, homeostatic mechanisms, and the significance of retinoid-binding proteins in maintaining ATRA levels. It highlights the intricate balance required for ATRA homeostasis, emphasizing that both excess and deficiency can lead to severe developmental and health consequences.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!