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Colorectal Cancer in Elderly Patients: Insights into Presentations, Prognosis, and Patient Outcomes.
Medicina (Kaunas)
November 2024
The Legacy Heritage Cancer Center, Dr. Larry Norton Institute, Soroka Medical Center, Beer-Sheva 84105, Israel.
: Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the third leading cause of cancer-related deaths. In 2020 alone, there were over 1.9 million new cases of CRC and nearly 0.
View Article and Find Full Text PDFBiobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
medRxiv
November 2024
Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Article Synopsis
- - The study highlights the complexity of Alzheimer's disease and related dementias, emphasizing the need to understand genetic and environmental factors that vary across different ancestries for personalized treatment approaches.
- - Utilizing large-scale biobank data, the research characterized genetic variants associated with Alzheimer's across 11 ancestries, identifying 116 potentially linked variants, including 18 known pathogenic ones and 98 new variants.
- - The findings revealed significant ancestry-driven differences in disease risk, including a higher presence of ε4/ε4 carriers in African ancestries, suggesting the importance of considering genetics in diverse populations to enhance understanding and treatment of AD/ADRDs.
Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens.
Microbiol Spectr
January 2025
Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China.
Persistent infection with high-risk human papillomavirus (HR-HPV) is the principal etiological factor of cervical cancer. Considering the gradual progression of cervical cancer, the early, rapid, sensitive, and specific identification of HPV, particularly HR-HPV types, is crucial in halting the advancement of the illness. Here, we established a rapid, highly sensitive, and specific HR-HPV detection platform, leveraging the CRISPR/Cas12a assay in conjunction with multienzyme isothermal rapid amplification.
View Article and Find Full Text PDFStructure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy.
Biochim Biophys Acta Rev Cancer
November 2024
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Weijin Road, Tianjin 300072, China. Electronic address:
Cancer remains one of the most difficult human diseases to overcome because of its complexity and diversity. Signal transducers and transcriptional activators 3 (STAT3) protein has been found to be overexpressed in a wide range of cancer types. Hyperactivation of STAT3 is particularly associated with low survival in cancer patients.
View Article and Find Full Text PDFPedestrians' Interaction with eHMI-equipped Autonomous Vehicles: A Bibliometric Analysis and Systematic Review.
Accid Anal Prev
January 2025
Department of Systems Engineering, City University of Hong Kong, Hong Kong, China; Shenzhen Research Institute, City University of Hong Kong, Shenzhen, China.
Autonomous vehicles (AVs) should prioritise pedestrian safety in a traffic accident. External human-machine interfaces (eHMIs), which enhance communication through visual and auditory signals, become essential as AVs become prevalent. This study aimed to investigate the current state of research on eHMIs, with a specific focus on pedestrian interactions with eHMI-equipped AVs.
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