AI Article Synopsis
- The study investigated how frusemide, amiloride, and bumetanide affect nasal transmucosal potential difference (NTPD) in 8 normal subjects during rest and exercise.
- At rest, only amiloride significantly reduced NTPD, while frusemide and bumetanide showed no substantial effects.
- During exercise, all substances except bumetanide caused a significant increase in NTPD, indicating that the medications influence nasal function differently under different conditions.
Article Abstract
The effects of application of frusemide, amiloride and bumetanide on nasal transmucosal potential difference (NTPD), at rest and during exercise, were studied in 8 normal subjects. In a double-blind placebo controlled study, 8 volunteers had NTPD recorded at 4-min intervals during 12-min periods of rest, before and after treatment, during 12 min of exercise, and recovery. Application of placebo, frusemide and bumetanide did not significantly alter NTPD at rest. Amiloride caused a significant reduction (P less than 0.025). During exercise there was a significant rise in NTPD with placebo (P less than 0.05), frusemide (P less than 0.05) and amiloride (P less than 0.05). There was no increase in NTPD during exercise with bumetanide.
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| http://dx.doi.org/10.1111/j.1365-2273.1992.tb01011.x | DOI Listing |
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