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Impaired maternal central hemodynamics precede the onset of vascular disorders of pregnancy at high altitude.
Am J Physiol Heart Circ Physiol
January 2025
Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Hypertensive disorders of pregnancy represent an escalating global health concern with increasing incidence in low- to middle-income countries and high-income countries alike. The current lack of methods to detect the subclinical stages of preeclampsia (PE) and fetal growth restriction (FGR), two common vascular disorders of pregnancy, limits treatment options to minimize acute- and long-term adverse outcomes for both mother and child. To determine whether impaired maternal cardiovascular or uteroplacental vascular function precedes the onset of PE and/or FGR (PE-FGR), we used noninvasive techniques to obtain serial measurements of maternal cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), and uterine and fetal arterial resistance at , -, and for 79 maternal-infant pairs in La Paz-El Alto, Bolivia (3,850 m), where the chronic hypoxia of high altitude increases the incidence of PE and FGR.
View Article and Find Full Text PDFPreeclampsia and transport of ions and small molecules: A literature review.
Placenta
October 2024
Graduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), 245 Sarmento Leite St, Porto Alegre, RS, ZIP 90050170, Brazil. Electronic address:
Article Synopsis
- - Preeclampsia (PE) affects 3-5% of pregnancies globally and can lead to severe health issues for both mothers and babies, including eclampsia, placental abruption, and stroke.
- - The condition is linked to diseases of the endothelial system and involves complex interactions of genetic, acquired, and immunological factors that disrupt normal placentation and blood flow.
- - Recent research highlights the role of ion transporters in uterine circulation during placentation, suggesting that their dysregulation due to adverse conditions can contribute significantly to the development of preeclampsia.
Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy.
Medicina (Kaunas)
September 2023
University Hospital "Dragisa Misovic", Heroja Milana Tepica 1, 11000 Belgrade, Serbia.
Stroke during pregnancy and preeclampsia are two distinct but interrelated medical conditions, sharing a common denominator-blood control failure. Along with cardiovascular diseases, diabetes, dyslipidemia, and hypercoagulability, hypertension is undoubtedly a major risk factor associated with stroke. Even though men have higher age-specific stroke rates, women are facing higher life-long stroke risk, primarily due to longer life expectancy.
View Article and Find Full Text PDFInfluence of accelerated arterial aging in growth-restricted cohorts on adult-onset cardiovascular diseases.
Am J Physiol Heart Circ Physiol
July 2023
Emeritus Head, Paediatric and Fetal Cardiac Units, Monash Health, Melbourne, Victoria, Australia.
Epidemiologists have long documented a higher risk of adult-onset cardiovascular diseases (CVDs) such as stroke, hypertension, and coronary artery disease, as well as mortality from circulatory causes in low birth-weight cohorts (poor in utero substrate supply). Utero-placental insufficiency and in utero hypoxemic state-induced alterations in arterial structure and compliance are important initiating factors for adult-onset hypertension. The mechanistic links between fetal growth restriction and CVD include decreased arterial wall elastin-to-collagen ratio, endothelial dysfunction, and heightened renin-angiotensin-aldosterone system (RAAS).
View Article and Find Full Text PDFPre-eclampsia.
Nat Rev Dis Primers
February 2023
Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia have reduced life expectancy, with increased risks of stroke, cardiovascular disease and diabetes, while babies from a pre-eclamptic pregnancy have increased risks of preterm birth, perinatal death and neurodevelopmental disability and cardiovascular and metabolic disease later in life. Pre-eclampsia is a complex multisystem disease, diagnosed by sudden-onset hypertension (>20 weeks of gestation) and at least one other associated complication, including proteinuria, maternal organ dysfunction or uteroplacental dysfunction.
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