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Group A Streptococcal Disease in Sudden Unexpected Death in Youth in the Pre- and Post-COVID-19 Era.
Pediatr Infect Dis J
February 2025
Department of Paediatrics, Juliana Children's Hospital Haga Hospital, the Hague, the Netherlands.
Background: An upsurge in pediatric invasive group A streptococcal infection (iGAS) has been observed in the Netherlands along with a suspected increase in iGAS-related sudden death. Sudden unexplained deaths in youth (SUDY) are investigated nationally through a standardized procedure [(Postmortem Evaluation of Sudden Unexplained Death in Youth (PESUDY)]. We investigate epidemiological differences between pediatric iGAS-related sudden deaths (iGAS-PESUDY) and surviving iGAS cases.
View Article and Find Full Text PDFCandidate transmission survival genome of .
Proc Natl Acad Sci U S A
March 2025
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065.
(Mtb), a leading cause of death from infection, completes its life cycle entirely in humans except for transmission through the air. To begin to understand how Mtb survives aerosolization, we mimicked liquid and atmospheric conditions experienced by Mtb before and after exhalation using a model aerosol fluid (MAF) based on the water-soluble, lipidic, and cellular constituents of necrotic tuberculosis lesions. MAF induced drug tolerance in Mtb, remodeled its transcriptome, and protected Mtb from dying in microdroplets desiccating in air.
View Article and Find Full Text PDFAssociation between neutrophil percentage-to-albumin ratio and mortality in Hemodialysis patients: insights from a prospective cohort study.
BMC Nephrol
March 2025
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.
Background: The neutrophil percentage-to-albumin ratio (NPAR) emerges as a novel inflammation marker, demonstrating prognostic ability in a variety of cardiovascular diseases. However, its impact on mortality among patients undergoing maintenance hemodialysis (MHD) remains uncertain. Our research aims to determine whether NPAR is a reliable predictor of mortality in MHD patients.
View Article and Find Full Text PDFEstablishment of an α-thalassemia mouse model through fetal liver cell transplantation and analysis of hematological parameters.
Sci Rep
February 2025
Shanghai Pharma Rare Disease Medicine Co., Ltd., Shanghai, 200000, China.
Clinically, α-thalassemia is stratified into mild, intermediate, and severe forms, differentiated by the degree of anemia severity. Specifically, severe α-thalassemia manifests in homozygous individuals, characterized by a profound α globin deficit. The presence of two α0 alleles, resulting in a complete four-gene defect (α), constitutes a lethal in utero condition known as Hemoglobin (Hb) Barts hydrops fetalis syndrome.
View Article and Find Full Text PDFTwo-year feasibility and safety of open-label autologous peripheral nerve tissue implantation during deep brain stimulation in patients with Parkinson's disease.
J Parkinsons Dis
February 2025
Neurorestoration Center, University of Kentucky, Lexington, KY, USA.
Background: Motor dysfunction in Parkinson's disease (PD) is characterized by a loss of functioning neurons in the substantia nigra. Two options exist when encountering damaged neurons: replace or support. We implemented a strategy of using autologous peripheral nerve tissue, in a reparative state, to provide a collection of neurorestorative support to unhealthy neurons with the goal of modifying the motor progression of PD.
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