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Behavioral variant of frontotemporal dementia in carriers of biallelic TREM2 variants: cases study.
Folia Neuropathol
August 2024
Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland.
Article Synopsis
- The study examines the role of mutations in the TREM2 gene, previously linked to Nasu-Hakola disease, in three unrelated patients diagnosed with the behavioral variant of frontotemporal dementia (bvFTD).
- Each patient was evaluated through various neurological, psychiatric, and cognitive assessments, revealing a correlation between specific TREM2 variants and bvFTD symptoms.
- Although the patients showed some clinical similarities to Nasu-Hakola disease, they exhibited distinct characteristics, including differences in age of onset, neuroimaging results, and disease progression.
Frontotemporal lobar degeneration in the "Annual of the Pathological Autopsy Cases in Japan".
J Neurol
August 2024
Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University, Mizuho, Nagoya, 467-8601, Japan.
Background: Good accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has been reported.
Objective: To assess the diagnostic accuracy of FTLD in an entire population, without restrictions related to patient age or diagnosing physician.
Methods: Volumes of the "Annual of the Pathological Autopsy Cases in Japan," with reports of 130,105 autopsies throughout Japan from 2007 to 2016, were descriptively analyzed.
LASIK is associated with early cataract surgery in healthy patients.
Int Ophthalmol
March 2024
Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico.
Purpose: To evaluate the association between LASIK and early cataract phacoemulsification surgery (PE).
Methods: A matched case-control study was conducted. Cases were otherwise healthy adults with a history of LASIK.
Pseudoexfoliative Syndrome in Cataract Surgery-A Quality Register Study and Health Economic Analysis in the Split-Dalmatia County, Croatia.
J Clin Med
December 2023
University of Split, School of Medicine, 21000 Split, Croatia.
Purpose: To investigate the impact of pseudoexfoliation (PEX) syndrome on intraoperative phacoemulsification (PHACO) parameters and assess the economic cost of PHACO surgery for cataracts in patients with and without PEX syndrome.
Methods: This was a retrospective quality register study on 5889 patients (6236 eyes) who underwent PHACO cataract surgery in the Eye Clinic, Clinical Hospital Centre Split, Croatia, over a 7-year period (May 2015 to December 2022), in accordance with the Guidelines of the Helsinki Declaration and approval from the Research Ethics Committee of the University Hospital Centre Split, Croatia. Inclusion criteria were patients with either presenile or senile cataract or cataract related to PEX syndrome who undertook PHACO procedure by the same experienced surgeon using the same PHACO device (Infiniti Vision System, Alcon Laboratories, Inc.
The role of brain perfusion SPECT in the diagnosis of frontotemporal dementia: A systematic review.
J Neuroimaging
May 2024
Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Background And Purpose: Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. The clinical distinction between FTD, Alzheimer's disease (AD), and other dementias is a clinical challenge. Brain perfusion SPECT may contribute to the diagnosis of FTD, but its value is unclear.
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